4-羟基苯乙腈

4-羟基苯乙腈是一种天然存在的腈类有机物，化学式为C₈H₇NO。它是白芥中白芥子苷的代谢产物之一。^[1]

4-羟基苯乙腈
识别
CAS号	14191-95-8  Y
PubChem	26548
SMILES	N#CCC1=CC=C(O)C=C1
性质
化学式	C8H7NO
摩尔质量	133.15 g·mol⁻¹
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

合成

4-羟基苯乙腈可由4-羟基苯乙酰胺催化脱水制得；^[2]或由4-氨基苯乙腈和亚硝酸钠、硫酸反应得到。^[3]

参考文献

1. Vladimir Borek, Matthew J. Morra, Ionic Thiocyanate (SCN - ) Production from 4-Hydroxybenzyl Glucosinolate Contained in Sinapis alba Seed Meal, Journal of Agricultural and Food Chemistry 53 (22), 2005-11-01, 53 (22): 8650–8654, doi:10.1021/jf051570r
2. Shishuai Ren, Yangyang Wang, Fei Yang, Hongjian Sun, Xiaoyan Li. Dehydration of primary amides to nitriles catalyzed by [CNC]-pincer hydrido cobalt(III) complexes. Catalysis Communications, 2019. 120: 72-75. doi:10.1016/j.catcom.2018.12.002.
3. Pschorr, R. Synthetic research in the phenanthrene series: Synthesis of pseudo-thebaol. Berichte der Deutschen Chemischen Gesellschaft, 1900. 33: 176-183. doi:10.1002/cber.19000330122.