3-羟基吡啶-2-甲酸

3-羟基吡啶-2-甲酸是一种有机化合物，化学式为C₆H₅NO₃，它可通过3-氨基吡啶-2-甲酸的重氮化反应制得，它在214~215 °C分解。^[1]它和金属盐反应，可以得到相应的配合物。^[2][3]它和甲醇在硫酸存在下回流反应，可以得到3-羟基吡啶-2-甲酸甲酯。^[4]

3-羟基吡啶-2-甲酸
IUPAC名 3-Hydroxypyridine-2-carboxylic acid
别名	3-Hydroxypicolinic acid 3-Hydroxy-2-pyridinecarboxylic acid
识别
CAS号	874-24-8  Y
PubChem	13401
ChemSpider	12827
SMILES	C1=CC(=C(N=C1)C(=O)O)O
InChI	1/C6H5NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-3,8H,(H,9,10)
InChIKey	BRARRAHGNDUELT-UHFFFAOYAC
ChEBI	63432
性质
化学式	C6H5NO3
摩尔质量	139.109 g·mol⁻¹
外观	浅黄色针状晶体
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

参考文献

1. Lewis R. Fibel, Paul E. Spoerri. The Synthesis and Investigation of Pyridine and Pyrazine Analogs of Salicylates 1,2. Journal of the American Chemical Society. 1948-11, 70 (11): 3908–3911 [2022-03-09]. ISSN 0002-7863. doi:10.1021/ja01191a113. （原始内容存档于2022-03-09） （英语）.
2. Boris-Marko Kukovec, Pedro D.Vaz, Maria José Calhorda, Zora Popović. Structural preferences and isomerism in nickel(II) and copper(II) complexes with 3-hydroxypicolinic acid. Polyhedron. 2012-05, 39 (1): 66–75 [2022-03-09]. doi:10.1016/j.poly.2012.03.040. （原始内容存档于2020-02-19） （英语）.
3. Tanja Koleša-Dobravc, Keiichi Maejima, Yutaka Yoshikawa, Anton Meden, Hiroyuki Yasui, Franc Perdih. Bis(picolinato) complexes of vanadium and zinc as potential antidiabetic agents: synthesis, structural elucidation and in vitro insulin-mimetic activity study. New Journal of Chemistry. 2018, 42 (5): 3619–3632 [2022-03-09]. ISSN 1144-0546. doi:10.1039/C7NJ04189F （英语）.
4. Tatiana N. Pashirova, Anissa Braïki, Irina V. Zueva, Konstantin A. Petrov, Vasily M. Babaev, Evgenia A. Burilova, Darya A. Samarkina, Ildar Kh. Rizvanov, Eliana B. Souto, Ludovic Jean, Pierre-Yves Renard, Patrick Masson, Lucia Ya. Zakharova, Oleg G. Sinyashin. Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection. Journal of Controlled Release. 2018-11, 290: 102–111 [2022-03-09]. doi:10.1016/j.jconrel.2018.10.010. （原始内容存档于2021-03-08） （英语）.