震颤素(英语:Tremorine)是一种在科学研究中使动物产生震颤的药物。这种物质被用于开发治疗帕金森病的药物,因为震颤是帕金森病的主要症状之一。[1][2][3][4][5]β受体阻滞剂也能有效抵消震颤素的影响。[6]
Quick Facts 临床资料, ATC码 ...
震颤素 |
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ATC码 | |
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1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine
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CAS号 | 51-73-0 |
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CompTox Dashboard (EPA) | |
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化学式 | C12H20N2 |
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摩尔质量 | 192.31 g·mol−1 |
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3D模型(JSmol) | |
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InChI=1S/C12H20N2/c1-2-8-13(7-1)11-5-6-12-14-9-3-4-10-14/h1-4,7-12H2 Key:JSUAJTLKVREZHV-UHFFFAOYSA-N
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震颤素是由埃弗里特等人于1956—57年首先报道的。[7][8][9][10]
Menon M, Clark WG, Aures D. Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats. Pharmacological Research Communications. 1971, 3 (4): 345–350. doi:10.1016/0031-6989(71)90005-1.
Paul V. The role of adrenergic mechanism in tremorine-induced tremors in rats: antitremor effect of beta-adrenoceptor antagonists. Indian Journal of Physiology and Pharmacology. 1986, 30 (4): 307–12. PMID 2883120.
Everett, Guy M. (1956). "Tremor produced by drugs". Nature v. 177(4522), p. 1238. ("In the routine screening of drugs in mice, we have found only ten out of ten thousand
compounds which produce sustained tremor. One of these, 1-4 dipyrrolidino-2-butyne, 'Tremorine', in doses of 5–20 mgm./kgm. produces tremor, salivation, meiosis, etc."
Everett G.M., Blockus L.E. and Sheppard I.M. (1956). "Tremor induced by tremorine and its antagonism by anti-Parkinson drugs." Science v. 124, p.79.
Everett G.M., Blockus L.E., Sheppard I.M. and Toman J.E.P. (1956), Federation Proceedings v. 15, p. 420.
Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", Federation Proceedings v. 16(1), p. 283.