阿端卫,明朝关西八卫之一,在今青海省朵斯库勒湖和新疆维吾尔自治区交界处。
明朝初年,元朝安定王卜颜帖木儿率领撒里畏兀儿投降明朝。洪武八年(1375年),在其地设立阿端卫,洪武中,朵尔只巴袭击,一度废除。永乐四年(1406年)其首领小薛忽鲁札请求,重新设立,明成祖命他为指挥佥事。洪熙年间,阿端卫被安定卫合并。
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