载脂蛋白C1

载脂蛋白C1（英语：Apolipoprotein C-I）是一个由人类基因 APOC1 编码的脂蛋白^[1][2]。

Apolipoprotein C-I 载脂蛋白C1
PDB rendering based on 1ioj.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1ALE, 1ALF, 1IOJ, 1OPP
标识
代号	APOC1
扩展标识	遗传学：107710 鼠基因：88053 同源基因：1244 GeneCards: APOC1 Gene
基因本体论描述 分子功能 · phospholipase inhibitor activity · fatty acid binding · phosphatidylcholine binding · lipase inhibitor activity · phosphatidylcholine-sterol O-acyltransferase activator activity 细胞成分 · endoplasmic reticulum · very-low-density lipoprotein particle · high-density lipoprotein particle · chylomicron 生物过程 · lipid metabolic process · positive regulation of cholesterol esterification · negative regulation of phosphatidylcholine catabolic process · negative regulation of very-low-density lipoprotein particle clearance · regulation of cholesterol transport · negative regulation of cholesterol transport · cholesterol efflux · phospholipid efflux · plasma lipoprotein particle remodeling · high-density lipoprotein particle remodeling · very-low-density lipoprotein particle assembly · chylomicron remnant clearance · very-low-density lipoprotein particle clearance · lipoprotein metabolic process · negative regulation of fatty acid biosynthetic process · negative regulation of lipid metabolic process · negative regulation of receptor-mediated endocytosis · negative regulation of lipid catabolic process · negative regulation of lipoprotein lipase activity Sources: Amigo / QuickGO
直系同源体
物种	人类	小鼠
Entrez	341	11812
Ensembl	ENSG00000130208	ENSMUSG00000040564
UniProt	P02654	P34928
mRNA序列	NM_001645	NM_001110009
蛋白序列	NP_001636	NP_001103479
基因位置	Chr 19: 45.42 – 45.42 Mb	Chr 7: 19.69 – 19.69 Mb
PubMed查询	[1]	[2]
查 论 编

ApoC-I
structural studies of a baboon (papio sp.) plasma protein inhibitor of cholesteryl ester transferase.
鉴定
标志	ApoC-I
Pfam	PF04691（旧版）
InterPro（英语：InterPro）	IPR006781
SCOP（英语：Structural Classification of Proteins）	1ale / SUPFAM
现有可用的蛋白结构： Pfam 结构（旧版） / ECOD PDB RCSB PDB; PDBe; PDBj PDBsum（英语：PDBsum） 结构概要

功能

该基因编码的蛋白质是载脂蛋白C（英语：apolipoprotein C）家族中的一员。

参考文献

1. Tata F, Henry I, Markham AF, Wallis SC, Weil D, Grzeschik KH, Junien C, Williamson R, Humphries SE. Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19. Hum. Genet. 1985, 69 (4): 345–9. PMID 2985493. doi:10.1007/BF00291654.
2. Smit M, van der Kooij-Meijs E, Frants RR, Havekes L, Klasen EC. Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia. Hum. Genet. January 1988, 78 (1): 90–3. PMID 2892779. doi:10.1007/BF00291243.

进一步阅读

• Shulman RS, Herbert PN, Wehrly K, Fredrickson DS. Thf complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins. J. Biol. Chem. 1975, 250 (1): 182–90. PMID 166984.
• Lauer SJ, Walker D, Elshourbagy NA; et al. Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene. J. Biol. Chem. 1988, 263 (15): 7277–86. PMID 2835369. 引文格式1维护：显式使用等标签 (link)
• Smit M, van der Kooij-Meijs E, Woudt LP; et al. Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene. Biochem. Biophys. Res. Commun. 1988, 152 (3): 1282–8. PMID 2897845. doi:10.1016/S0006-291X(88)80424-8. 引文格式1维护：显式使用等标签 (link)
• Davison PJ, Norton P, Wallis SC; et al. There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene for apo E. Biochem. Biophys. Res. Commun. 1986, 136 (3): 876–84. PMID 3013172. doi:10.1016/0006-291X(86)90414-6. 引文格式1维护：显式使用等标签 (link)
• Myklebost O, Rogne S. The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19. Hum. Genet. 1986, 73 (4): 286–9. PMID 3017837. doi:10.1007/BF00279087.
• Jackson RL, Sparrow JT, Baker HN; et al. The primary structure of apolopoprotein-serine. J. Biol. Chem. 1974, 249 (16): 5308–13. PMID 4369340. 引文格式1维护：显式使用等标签 (link)
• Knott TJ, Robertson ME, Priestley LM; et al. Characterisation of mRNAs encoding the precursor for human apolipoprotein CI. Nucleic Acids Res. 1984, 12 (9): 3909–15. PMC 318798 . PMID 6328444. doi:10.1093/nar/12.9.3909. 引文格式1维护：显式使用等标签 (link)
• Servillo L, Brewer HB, Osborne JC. Evaluation of the mixed interaction between apolipoproteins A-II and C-I equilibrium sedimentation. Biophys. Chem. 1981, 13 (1): 29–38. PMID 6789904. doi:10.1016/0301-4622(81)80022-1.
• Curry MD, McConathy WJ, Fesmire JD, Alaupovic P. Quantitative determination of apolipoproteins C-I and C-II in human plasma by separate electroimmunoassays. Clin. Chem. 1981, 27 (4): 543–8. PMID 7471419.
• Rozek A, Buchko GW, Cushley RJ. Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy. Biochemistry. 1995, 34 (22): 7401–8. PMID 7779782. doi:10.1021/bi00022a013.
• Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 1994, 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
• Trask B, Fertitta A, Christensen M; et al. Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. Genomics. 1993, 15 (1): 133–45. PMID 8432525. doi:10.1006/geno.1993.1021. 引文格式1维护：显式使用等标签 (link)
• Kamino K, Yoshiiwa A, Nishiwaki Y; et al. Genetic association study between senile dementia of Alzheimer's type and APOE/C1/C2 gene cluster. Gerontology. 1996,. 42 Suppl 1: 12–9. PMID 8804993. doi:10.1159/000213820. 引文格式1维护：显式使用等标签 (link)
• Rozek A, Buchko GW, Kanda P, Cushley RJ. Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy. Protein Sci. 1998, 6 (9): 1858–68. PMC 2143781 . PMID 9300485. doi:10.1002/pro.5560060906.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 1997, 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 引文格式1维护：显式使用等标签 (link)
• Halushka MK, Fan JB, Bentley K; et al. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat. Genet. 1999, 22 (3): 239–47. PMID 10391210. doi:10.1038/10297. 引文格式1维护：显式使用等标签 (link)
• Freitas EM, Zhang WJ, Lalonde JP; et al. Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1. DNA Seq. 1999, 9 (2): 89–100. PMID 10520737. doi:10.3109/10425179809086433. 引文格式1维护：显式使用等标签 (link)
• Gautier T, Masson D, de Barros JP; et al. Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity. J. Biol. Chem. 2001, 275 (48): 37504–9. PMID 10978346. doi:10.1074/jbc.M007210200. 引文格式1维护：显式使用等标签 (link)
• Hartley JL, Temple GF, Brasch MA. DNA cloning using in vitro site-specific recombination. Genome Res. 2001, 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.