莫沙必利(英语:Mosapride),是一种消化道促动力药,选择性激动5-HT4受体,其主要代谢产物M1还具有5HT3受体的竞争性拮抗作用。[1]莫沙必利可以加速胃排空,促进全消化道的蠕动,用来治疗胃炎、胃食管反流病、功能性消化不良和过敏性肠综合征[2][3][4][5],也做为止吐剂,较不会诱发椎体外症候群[6]。枸缘酸盐形式的莫沙必利,由大日本住友制药在1998年以加斯清为商品名上市销售。
Quick Facts 临床资料, AHFS/Drugs.com ...
莫沙必利 |
|
|
AHFS/Drugs.com | 国际药品名称 |
---|
给药途径 | 口服 |
---|
ATC码 | |
---|
|
(RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide
|
CAS号 | 112885-41-3 Y |
---|
PubChem CID | |
---|
IUPHAR/BPS | |
---|
ChemSpider | |
---|
UNII | |
---|
KEGG | |
---|
ChEMBL | |
---|
CompTox Dashboard (EPA) | |
---|
ECHA InfoCard | 100.127.999 |
---|
|
化学式 | C21H25ClFN3O3 |
---|
摩尔质量 | 421.893 g/mol |
---|
3D模型(JSmol) | |
---|
Clc1cc(c(OCC)cc1N)C(=O)NCC3OCCN(Cc2ccc(F)cc2)C3
|
InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27) YKey:YPELFRMCRYSPKZ-UHFFFAOYSA-N Y
|
Close
维基百科中的医学内容
仅供参考,并
不能视作专业意见。如需获取医疗帮助或意见,请咨询专业人士。详见
医学声明。
- 蕈毒碱拮抗剂(Muscarinic antagonist、蕈毒碱性受体拮抗剂)
Tack, J.; Camilleri, M.; Chang, L.; Chey, WD.; Galligan, JJ.; Lacy, BE.; Müller-Lissner, S.; Quigley, EM.; Schuurkes, J. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.. Aliment Pharmacol Ther. Apr 2012, 35 (7): 745–67. PMID 22356640. doi:10.1111/j.1365-2036.2012.05011.x.
Odaka T, Suzuki T, Seza A, Yamaguchi T, Saisho H. [Serotonin 5- HT4 receptor agonist (mosapride citrate)]. Nippon Rinsho. August 2006, 64 (8): 1491–4. PMID 16898619 (日语).
Mizuta Y, Shikuwa S, Isomoto H, Mishima R, Akazawa Y, Masuda J, Omagari K, Takeshima F, Kohno S. Recent insights into digestive motility in functional dyspepsia. Journal of Gastroenterology. 2006 Nov;41(11):1025-40.
Kato S, Morie T, Yoshida N. Synthesis and biological activities of metabolites of mosapride, a new gastroprokinetic agent.Chemical and Pharmaceutical Bulletin (Tokyo). 1995 Apr;43(4):699-702.