甲酚曲唑三硅氧烷

甲酚曲唑三硅氧烷
	IUPAC名; 2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol
	系统名; 2-(2H-1,2,3-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-(2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptan-4-yl)propyl]phenol
别名	Mexoryl XL; Silatrizole
识别
CAS号	155633-54-8 ?
PubChem	9848888
ChemSpider	8024601
SMILES	CC(CC1=C(O)C(=CC(C)=C1)N1N=C2C=CC=CC2=N1)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C;
性质
化学式	C24H39N3O3Si3
摩尔质量	501.84 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

甲酚曲唑三硅氧烷（INCI：drometrizole trisiloxane）脂溶性苯并三唑衍生物。是一种防晒剂，于1989由欧莱雅开发，商品名Mexoryl XL。甲酚曲唑三硅氧烷为广谱紫外线吸收剂，最大吸收峰为303 nm（UVB）和344 nm（UVA），其常与对苯二亚甲基二樟脑磺酸联合作用，产生协同效应^[1]。

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甲酚曲唑三硅氧烷已经在欧盟^[2]、加拿大^[3]、澳大利亚^[4] 、日本^[5]等国家批准使用，但美国尚未批准。

[1]
Moyal D. Prevention of ultraviolet-induced skin pigmentation. Photodermatol Photoimmunol Photomed. October 2004, 20 (5): 243–7. PMID 15379874. S2CID 22120937. doi:10.1111/j.1600-0781.2004.00111.x.
[2]
COUNCIL DIRECTIVE of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products (PDF). [2024-07-05]. （原始内容存档 (PDF)于2008-08-14）.
[3]
Sunburn Protectants 互联网档案馆的存档，存档日期March 11, 2009，., Health Canada
[4]
Australian Regulatory Guidelines for OTC Medicines - Chapter 10 (PDF). [2024-07-05]. （原始内容存档 (PDF)于2009-10-28）.
[5]
Forestier, S.; Ortiz, S; Jitsukawa Setsuko. Mexoryl XL: A new UV protective agent. Fragr J. 2004, 32 (4): 59–64 [2008-08-01]. （原始内容存档于2009-10-28）.

[1] [1]
Moyal D. Prevention of ultraviolet-induced skin pigmentation. Photodermatol Photoimmunol Photomed. October 2004, 20 (5): 243–7. PMID 15379874. S2CID 22120937. doi:10.1111/j.1600-0781.2004.00111.x.

[2] [2]
COUNCIL DIRECTIVE of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products (PDF). [2024-07-05]. （原始内容存档 (PDF)于2008-08-14）.

[3] [3]
Sunburn Protectants 互联网档案馆的存档，存档日期March 11, 2009，., Health Canada

[4] [4]
Australian Regulatory Guidelines for OTC Medicines - Chapter 10 (PDF). [2024-07-05]. （原始内容存档 (PDF)于2009-10-28）.

[5] [5]
Forestier, S.; Ortiz, S; Jitsukawa Setsuko. Mexoryl XL: A new UV protective agent. Fragr J. 2004, 32 (4): 59–64 [2008-08-01]. （原始内容存档于2009-10-28）.

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批准

参考文献

甲酚曲唑三硅氧烷


IUPAC名 2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol
系统名 2-(2H-1,2,3-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-(2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptan-4-yl)propyl]phenol
别名	Mexoryl XL Silatrizole
识别
CAS号	155633-54-8 ^?
PubChem	9848888
ChemSpider	8024601
SMILES	CC(CC1=C(O)C(=CC(C)=C1)N1N=C2C=CC=CC2=N1)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C
性质
化学式	C₂₄H₃₉N₃O₃Si₃
摩尔质量	501.84 g·mol⁻¹
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。