弘治年间,嗣世职,为榆林卫指挥使。因御史胡希颜举荐,进都指挥佥事,充延绥游击将军。弘治十八年,率众击退蒙古入侵宁夏。明武宗继位后,蒙古大举进犯宣府、大同,姜汉与副总兵曹雄、参将王戟分道驰援并有功。之后替代曹雄担任副总兵,协守延绥。正德三年,移守凉州。次年,擢署都督佥事,充总兵官,镇守宁夏。姜汉驭军严整,得将士心,数月后,明安化王朱寘𫔍谋逆,置酒召姜汉及巡抚安惟学等入宴,其中派其党羽何锦率众入。姜汉不屈而亡。其子姜奭逃免。平定叛乱后,诏赐祭葬[1]。
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