卡莫司他(英语:camostat,开发代码FOY-305),是一种丝氨酸蛋白酶抑制剂,在体内有各种功能。被用来治疗某些肿瘤,并被用来有效地抵抗病毒感染。还可抑制肝脏纤维化、肾病或胰腺炎。[1][2][3][4][5]在日本被批准使用。[6]
2020年德国科学家在细胞杂志上发表论文指出甲磺酸卡莫司他(英语:camostat mesylate)积极对抗TMPRSS2,部分阻断SARS-2-S-驱动的进入Caco-2和Vero195 TMPRSS2细胞。[7]
Quick Facts 临床资料, 商品名(英语:Drug nomenclature) ...
卡莫司他![Thumb](//upload.wikimedia.org/wikipedia/commons/thumb/0/0b/Camostat.svg/220px-Camostat.svg.png) |
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商品名 | Foipan |
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AHFS/Drugs.com | 国际药品名称 |
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给药途径 | Oral |
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ATC码 | |
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法律规范 |
- 美:Not FDA approved
- 处方药(℞-only)
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N,N-Dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate
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CAS号 | 59721-28-7 Y |
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PubChem CID | |
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IUPHAR/BPS | |
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ChemSpider | |
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UNII | |
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ChEMBL | |
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CompTox Dashboard (EPA) | |
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化学式 | C20H22N4O5 |
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摩尔质量 | 398.42 g·mol−1 |
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3D模型(JSmol) | |
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CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N
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InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23) YKey:XASIMHXSUQUHLV-UHFFFAOYSA-N Y
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Kitamura, K.; Tomita, K. Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension. Clinical and Experimental Nephrology. 2012, 16 (1): 44–8. PMID 22038264. doi:10.1007/s10157-011-0506-1.
Zhou, Y.; Vedantham, P.; Lu, K.; Agudelo, J.; Carrion Jr, R.; Nunneley, J. W.; Barnard, D.; Pöhlmann, S.; McKerrow, J. H.; Renslo, A. R.; Simmons, G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Research. 2015, 116: 76–84. PMC 4774534
. PMID 25666761. doi:10.1016/j.antiviral.2015.01.011.
Ueda, M.; Uchimura, K.; Narita, Y.; Miyasato, Y.; Mizumoto, T.; Morinaga, J.; Hayata, M.; Kakizoe, Y.; Adachi, M.; Miyoshi, T.; Shiraishi, N.; Kadowaki, D.; Sakai, Y.; Mukoyama, M.; Kitamura, K. The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects. Nephron. 2015, 129 (3): 223–32. PMID 25766432. doi:10.1159/000375308.