一叶萩碱(浅黄色晶体,化学式:C13H15NO2)是一种发现于一叶萩[1]和珠子草[2]的含氮有机化合物,属于八氢吲嗪类生物碱。它具有促惊厥作用,[3][4]且具有强烈的痉挛作用,类似于士的宁。[5]它是一种GABA-A拮抗剂。[6][7]
Quick Facts 识别信息, CAS号 ...
一叶萩碱 |
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(1S,2R,8S)-14-Oxa-7-azatetracyclo[6.6.1.01,11.02,7]pentadeca-9,11-dien-13-one
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CAS号 | 5610-40-2 |
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PubChem CID | |
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ChemSpider | |
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UNII | |
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KEGG | |
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ChEBI | |
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ChEMBL | |
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CompTox Dashboard (EPA) | |
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ECHA InfoCard | 100.222.962 |
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化学式 | C13H15NO2 |
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摩尔质量 | 217.27 g·mol−1 |
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3D模型(JSmol) | |
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C1CCN2[C@H](C1)[C@]34C[C@H]2C=CC3=CC(=O)O4
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InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1 Key:SWZMSZQQJRKFBP-WZRBSPASSA-N
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Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK. Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review. Journal of Ethnopharmacology. November 2011, 138 (2): 286–313. PMID 21982793. doi:10.1016/j.jep.2011.09.040.
Tao, S. C.; Peng, J. Z.; Lu, M. W. Central convulsive action of l-securinine. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica. 1986, 7 (1): 9–12. PMID 2876581.
Zhang, S. C.; Li, S. Z.; Gao, X. C.; Qian, L. H.; Yang, M. Z.; Yuan, H. N.; Tan, D. J. The adverse effects of the preparations of the active principles of Chinese herbal drugs. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 1993, 18 (7): 387–391. PMID 8267848.
Securinine. PubChem, US National Library of Medicine. 2020-07-04 [2022-12-27]. (原始内容存档于2022-12-27).