PRNP

朊毒体蛋白
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1E1G、1E1J、1E1P、1E1S、1E1U、1E1W、1FKC、1FO7、1H0L、1HJM、1HJN、1I4M、1OEH、1OEI、1QLX、1QLZ、1QM0、1QM1、1QM2、1QM3、2IV4、2IV5、2IV6、2K1D、2KUN、2LBG、2LEJ、2LFT、2LSB、2LV1、2OL9、2W9E、3HAF、3HAK、3HEQ、3HER、3HES、3HJ5、3HJX、3MD4、3MD5、3NHC、3NHD、3NVF、4DGI、4E1H、4E1I,%%s1E1G、1E1J、1E1P、1E1S、1E1U、1E1W、1FKC、1FO7、1H0L、1HJM、1HJN、1I4M、1OEH、1OEI、1QLX、1QLZ、1QM0、1QM1、1QM2、1QM3、2IV4、2IV5、2IV6、2K1D、2KUN、2LBG、2LEJ、2LFT、2LSB、2LV1、2M8T、2W9E、3HAF、3HAK、3HEQ、3HER、3HES、3HJ5、3HJX、3MD4、3MD5、3NHC、3NVF、4DGI、4E1H、4E1I、4KML、4N9O
识别号
别名	PRNP；, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein
外部ID	OMIM：176640 MGI：97769 HomoloGene：7904 GeneCards：PRNP
相关疾病
	传染性海绵状脑病、克雅二氏病、致死性家族失眠症、Gerstmann–Sträussler–Scheinker症候群、Huntington disease-like 1、spongiform encephalopathy with neuropsychiatric features、inherited Creutzfeldt–Jakob disease
基因位置（人类）
染色体	20号染色体
终止	4,701,590 bp
基因位置（小鼠）
染色体	小鼠2号染色体
终止	131,780,349 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• chaperone binding; • transmembrane transporter binding; • microtubule binding; • ATP-dependent protein binding; • 金属离子结合; • tubulin binding; • 血浆蛋白结合; • 相同蛋白质结合; • copper ion binding; • lamin binding; • amyloid-beta binding; • 蛋白酶结合; • glycosaminoglycan binding; • type 5 metabotropic glutamate receptor binding; • type 8 metabotropic glutamate receptor binding; • signaling receptor activity; • 大分子复合物结合; • cupric ion binding; • cuprous ion binding;
细胞组分	• mitochondrial outer membrane; • 膜; • 线粒体; • integral component of membrane; • 细胞质; • 高尔基体; • 细胞膜; • cell surface; • 内质网; • 脂筏模型; • anchored component of membrane; • 外排体; • 细胞核; • extrinsic component of membrane; • 细胞质基质; • 突触后致密物质; • 包涵体; • 树突; • anchored component of external side of plasma membrane; • 核膜; • 细胞内膜结合细胞器; • postsynapse;
生物学过程	• negative regulation of protein phosphorylation; • negative regulation of interferon-gamma production; • response to cadmium ion; • negative regulation of calcineurin-NFAT signaling cascade; • response to copper ion; • negative regulation of apoptotic process; • response to oxidative stress; • negative regulation of DNA-binding transcription factor activity; • negative regulation of T cell receptor signaling pathway; • regulation of protein localization; • negative regulation of activated T cell proliferation; • 学习和记忆; • cellular copper ion homeostasis; • cellular response to copper ion; • 细胞周期; • 代谢; • negative regulation of interleukin-17 production; • protein homooligomerization; • negative regulation of interleukin-2 production; • regulation of potassium ion transmembrane transport; • 长期记忆; • positive regulation of cell death; • negative regulation of protein processing; • protein destabilization; • activation of protein kinase activity; • calcium-mediated signaling using intracellular calcium source; • negative regulation of catalytic activity; • positive regulation of neuron apoptotic process; • regulation of peptidyl-tyrosine phosphorylation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of protein tyrosine kinase activity; • positive regulation of protein targeting to membrane; • dendritic spine maintenance; • negative regulation of long-term synaptic potentiation; • regulation of glutamate receptor signaling pathway; • positive regulation of neuron death; • negative regulation of amyloid-beta formation; • regulation of intracellular calcium activated chloride channel activity; • negative regulation of dendritic spine maintenance; • negative regulation of amyloid precursor protein catabolic process; • positive regulation of protein localization to plasma membrane; • response to amyloid-beta; • cellular response to amyloid-beta; • regulation of calcium ion import across plasma membrane; • neuron projection maintenance;
	Sources:Amigo / QuickGO
直系同源
	5621
	19122
	ENSG00000171867
	ENSMUSG00000079037
	P04156
	P04925
NM_183079; NM_000311; NM_001080121; NM_001080122; NM_001080123;
	NM_001271561
	NM_001278256; NM_011170
NP_000302; NP_001073590; NP_001073591; NP_001073592; NP_001258490;
	NP_898902; NP_000302.1; NP_001073590.1; NP_001073591.1; NP_001073592.1; NP_898902.1
	NP_001265185; NP_035300
	维基数据
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