LAMA1位於18號人類染色體的基因 / 维基百科,自由的 encyclopedia 层粘连蛋白亚基α1是一个层粘连蛋白的蛋白亚基。层粘蛋白是一种组成核纤层的蛋白,在细胞核的形态维持中扮演重要角色。此蛋白质在人体内由LAMA1基因编码[7][8]。 Quick Facts LAMA1, 已知的结构 ...LAMA1已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表2JD4识别号别名LAMA1;, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1外部IDOMIM:150320 MGI:99892 HomoloGene:21146 GeneCards:LAMA1 相关疾病2型糖尿病、ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome[1]为以下药物的标靶ocriplasmin[2]基因位置(人类)染色体18号染色体[3]基因座18p11.31起始6,941,742 bp[3]终止7,117,797 bp[3]基因位置(小鼠)染色体小鼠17号染色体[4]基因座17 E1.1|17 38.8 cM起始68,004,254 bp[4]终止68,129,642 bp[4]RNA表达模式查阅更多表达数据基因本体分子功能• signaling receptor binding• extracellular matrix structural constituent• 血浆蛋白结合• protein C-terminus binding• glycosphingolipid binding细胞组分• 细胞外间质• 细胞外区域• 基底膜• laminin-1 complex• laminin-3 complex• 细胞外空间• 膜• cell-cell junction• laminin complex• collagen-containing extracellular matrix生物学过程• cell surface receptor signaling pathway• regulation of cell adhesion• 细胞粘附• extracellular matrix organization• regulation of cell migration• regulation of embryonic development• morphogenesis of an epithelial sheet• protein phosphorylation• 组织发生• neuron projection development• establishment of epithelial cell apical/basal polarity• retina development in camera-type eye• epithelial tube branching involved in lung morphogenesis• branching involved in salivary gland morphogenesis• retinal blood vessel morphogenesis• 轴突导向• animal organ morphogenesis• camera-type eye development• blood vessel morphogenesisSources:Amigo / QuickGO直系同源物种人类小鼠Entrez28421716772EnsemblENSG00000101680ENSMUSG00000032796UniProtP25391P19137mRNA序列NM_005559NM_008480蛋白序列NP_005550NP_032506基因位置(UCSC)Chr 18: 6.94 – 7.12 MbChr 17: 68 – 68.13 MbPubMed查找[5][6]维基数据查看/编辑人类查看/编辑小鼠Close
层粘连蛋白亚基α1是一个层粘连蛋白的蛋白亚基。层粘蛋白是一种组成核纤层的蛋白,在细胞核的形态维持中扮演重要角色。此蛋白质在人体内由LAMA1基因编码[7][8]。 Quick Facts LAMA1, 已知的结构 ...LAMA1已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表2JD4识别号别名LAMA1;, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1外部IDOMIM:150320 MGI:99892 HomoloGene:21146 GeneCards:LAMA1 相关疾病2型糖尿病、ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome[1]为以下药物的标靶ocriplasmin[2]基因位置(人类)染色体18号染色体[3]基因座18p11.31起始6,941,742 bp[3]终止7,117,797 bp[3]基因位置(小鼠)染色体小鼠17号染色体[4]基因座17 E1.1|17 38.8 cM起始68,004,254 bp[4]终止68,129,642 bp[4]RNA表达模式查阅更多表达数据基因本体分子功能• signaling receptor binding• extracellular matrix structural constituent• 血浆蛋白结合• protein C-terminus binding• glycosphingolipid binding细胞组分• 细胞外间质• 细胞外区域• 基底膜• laminin-1 complex• laminin-3 complex• 细胞外空间• 膜• cell-cell junction• laminin complex• collagen-containing extracellular matrix生物学过程• cell surface receptor signaling pathway• regulation of cell adhesion• 细胞粘附• extracellular matrix organization• regulation of cell migration• regulation of embryonic development• morphogenesis of an epithelial sheet• protein phosphorylation• 组织发生• neuron projection development• establishment of epithelial cell apical/basal polarity• retina development in camera-type eye• epithelial tube branching involved in lung morphogenesis• branching involved in salivary gland morphogenesis• retinal blood vessel morphogenesis• 轴突导向• animal organ morphogenesis• camera-type eye development• blood vessel morphogenesisSources:Amigo / QuickGO直系同源物种人类小鼠Entrez28421716772EnsemblENSG00000101680ENSMUSG00000032796UniProtP25391P19137mRNA序列NM_005559NM_008480蛋白序列NP_005550NP_032506基因位置(UCSC)Chr 18: 6.94 – 7.12 MbChr 17: 68 – 68.13 MbPubMed查找[5][6]维基数据查看/编辑人类查看/编辑小鼠Close