CD14

CD14（cluster of differentiation 14，分化簇14）是一种细胞表面蛋白质，主要在先天免疫系统的巨噬细胞上表达^[5]，是最早发现的模式识别受体^[6]，能参与识别脂多糖（LPS，一种病原相关分子模式）。

CD14与TLR4等形成识别LPS的复合物

CD14
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4GLP
识别号
别名	CD14；, entrez:929, CD14 molecule
外部ID	OMIM：158120 MGI：88318 HomoloGene：493 GeneCards：CD14
基因位置（人类） 染色体 5号染色体[1] 基因座 5q31.3 起始 140,631,728 bp[1] 终止 140,633,700 bp[1]
基因位置（小鼠） 染色体 小鼠18号染色体[2] 基因座 18 B2|18 19.46 cM 起始 36,858,120 bp[2] 终止 36,859,851 bp[2]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • lipopolysaccharide binding • opsonin receptor activity • lipoteichoic acid binding • 血浆蛋白结合 • peptidoglycan immune receptor activity • lipopeptide binding 细胞组分 • 高尔基体 • 膜 • 细胞膜 • 细胞外区域 • cell surface • lipopolysaccharide receptor complex • anchored component of external side of plasma membrane • 脂筏模型 • anchored component of membrane • endosome membrane • 外排体 • external side of plasma membrane • 细胞外空间 • secretory granule membrane 生物学过程 • toll-like receptor TLR1:TLR2 signaling pathway • response to bacterium • toll-like receptor 4 signaling pathway • immune system process • cellular response to diacyl bacterial lipopeptide • positive regulation of interferon-gamma production • response to magnesium ion • response to heat • response to electrical stimulus • MyD88-dependent toll-like receptor signaling pathway • 受体介导的内吞作用 • cellular response to triacyl bacterial lipopeptide • TRIF-dependent toll-like receptor signaling pathway • response to tumor necrosis factor • positive regulation of endocytosis • cell surface receptor signaling pathway • response to lipopolysaccharide • cellular response to lipoteichoic acid • 吞噬作用 • positive regulation of tumor necrosis factor production • inflammatory response • response to ethanol • I-kappaB kinase/NF-kappaB signaling • toll-like receptor TLR6:TLR2 signaling pathway • cellular response to lipopolysaccharide • response to molecule of bacterial origin • positive regulation of type I interferon production • lipopolysaccharide-mediated signaling pathway • MyD88-independent toll-like receptor signaling pathway • 细胞凋亡 • 先天免疫系统 • 程序性坏死 • negative regulation of MyD88-independent toll-like receptor signaling pathway • apoptotic signaling pathway • toll-like receptor signaling pathway • neutrophil degranulation • positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	929	12475
Ensembl	ENSG00000170458	ENSMUSG00000051439
UniProt	P08571	P10810
mRNA​序列	NM_001174105 ​NM_000591 ​NM_001040021 ​NM_001174104	NM_009841
蛋白序列	NP_000582 ​NP_001035110 ​NP_001167575 ​NP_001167576	NP_033971
基因位置​（UCSC）	Chr 5: 140.63 – 140.63 Mb	Chr 18: 36.86 – 36.86 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. GRCh38: Ensembl release 89: ENSG00000170458 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051439 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S. Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. July 1989, 1008 (2): 213–222. PMID 2472171. doi:10.1016/0167-4781(80)90012-3.
6. Simmons DL, Tan S, Tenen DG, Nicholson-Weller A, Seed B. Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood. January 1989, 73 (1): 284–289. PMID 2462937. doi:10.1182/blood.V73.1.284.284 .

外部链接

• Human CD14 genome location and CD14 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
• PDB中UniProt可用的所有结构信息之概述：P08571 (Monocyte differentiation antigen CD14) 在PDBe-KB（英语：PDBe-KB）。
• 医学主题词表（MeSH）：CD14+Antigens