4-氟氯苯

4-氟氯苯是一种有机化合物，化学式为C₆H₄ClF。它可由氟苯、三氟化硼一水合物和N-氯代丁二酰亚胺反应制得；^[4]4-硝基氟苯和亚临界四氯化碳（250 °C，~7 MPa）反应，也能得到4-氟氯苯。^[5]它和苯硼酸在碱和催化剂的存在下反应，可以得到4-氟联苯。^[6]

4-氟氯苯
别名	对氟氯苯 4-氯氟苯 对氯氟苯
识别
CAS号	352-33-0  Y
性质
化学式	C6H4ClF
摩尔质量	130.55 g·mol−1
密度	1.2262 g·cm−3（25 °C）[1]
熔点	−21.5 °C（251.7 K）[2] −26.8 °C（246.3 K）[3]
沸点	129.5—130 °C（402.6—403.1 K）[2]
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

参考文献

1. Hongli Liu, Tomoko Yamashita, Tadashi Kamiyama, Masao Fujisawa, Takayoshi Kimura. Excess enthalpies of binary mixtures of ortho-, meta-, and para-structural isomers. Journal of Thermal Analysis and Calorimetry. 2010-01, 99 (1): 95–103 [2021-12-21]. ISSN 1388-6150. doi:10.1007/s10973-009-0483-8 （英语）.
2. Peter Kovacic, Neal O. Brace. Chlorination of Aromatic Compounds with Metal Chlorides. Journal of the American Chemical Society. 1954-11, 76 (21): 5491–5494 [2021-12-21]. ISSN 0002-7863. doi:10.1021/ja01650a069 （英语）.
3. "PhysProp" data were obtained from Syracuse Research Corporation of Syracuse, New York (US). Retrieved from SciFinder. [2021-12-21].
4. G. K. Surya Prakash, Thomas Mathew, Dushyanthi Hoole, Pierre M. Esteves, Qi Wang, Golam Rasul, George A. Olah. N -Halosuccinimide/BF 3 −H 2 O, Efficient Electrophilic Halogenating Systems for Aromatics. Journal of the American Chemical Society. 2004-12-01, 126 (48): 15770–15776 [2021-12-21]. ISSN 0002-7863. doi:10.1021/ja0465247. （原始内容存档于2021-12-21） （英语）.
5. Kiyoshi Tanemura, Tsuneo Suzuki, Yoko Nishida, Takaaki Horaguchi. Chlorination of various substrates in subcritical carbon tetrachloride. Tetrahedron. 2010-04, 66 (15): 2881–2888 [2021-12-21]. doi:10.1016/j.tet.2010.02.021 （英语）.
6. Raghu N. Dhital, Abhijit Sen, Takuma Sato, Hao Hu, Rikako Ishii, Daisuke Hashizume, Hikaru Takaya, Yasuhiro Uozumi, Yoichi M. A. Yamada. Activator-Promoted Aryl Halide-Dependent Chemoselective Buchwald–Hartwig and Suzuki–Miyaura Type Cross-Coupling Reactions. Organic Letters. 2020-06-19, 22 (12): 4797–4801 [2021-12-21]. ISSN 1523-7060. doi:10.1021/acs.orglett.0c01600 （英语）.