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脂氧合酶
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脂氧合酶[2](英语:Lipoxygenase,简称为LOX,EC 1.13.11.-)是一类含铁酶家族,催化脂类中含有顺,顺-1,4-戊二烯结构的多不饱和脂肪酸的双加氧化。主要催化以下过程:
- 脂肪酸 + O2 = 脂肪酸过氧化物
此条目需要扩充。 (2011年9月15日) |
Quick Facts 脂氧合酶, 鉴定 ...
脂氧合酶 | |||||||||||
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![]() 兔子网状细胞15S-脂氧合酶的结构[1]。 | |||||||||||
鉴定 | |||||||||||
标志 | Lipoxygenase | ||||||||||
Pfam | PF00305(旧版) | ||||||||||
InterPro(英语:InterPro) | IPR013819 | ||||||||||
PROSITE(英语:PROSITE) | PDOC00077 | ||||||||||
SCOP(英语:Structural Classification of Proteins) | 2sbl / SUPFAM | ||||||||||
OPM(英语:Orientations of Proteins in Membranes database)家族 | 87 | ||||||||||
OPM(英语:Orientations of Proteins in Membranes database)蛋白 | 1zq4 | ||||||||||
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脂氧合酶存在于植物、动物与真菌之中。脂氧合酶的产物涉及到多种细胞功能。
参考文献
- Choi J, Chon JK, Kim S, Shin W. Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data. Proteins. February 2008, 70 (3): 1023–32. PMID 17847087. doi:10.1002/prot.21590.
外部链接
- LOX-DB - LipOXygenases DataBase
- Lipoxygenases iron-binding region (页面存档备份,存于互联网档案馆) in PROSITE
- PDB 1YGE - structure of lipoxygenase-1 from soybean (Glycine max)
- PDB 1IK3 - structure of soybean lipoxygenase-3 in complex with (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoic acid
- PDB 1LOX - structure of rabbit 15-lipoxygenase in complex with inhibitor
- Template:UMichOPM - animal lipoxygenases
- 医学主题词表(MeSH):Lipoxygenase