甲状腺激素β受体位於3號人類染色體的基因 / 维基百科,自由的 encyclopedia 甲状腺激素β受体(TR-β,或THR-β)也称为核受体亚家族1,A 组,成员2(NR1A2),是一种核受体蛋白,在人类中由THR-β基因编码。[7][8] Quick Facts 甲状腺激素β受体, 已知的结构 ...甲状腺激素β受体已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表1BSX、1N46、1NAX、1NQ0、1NQ1、1NQ2、1NUO、1Q4X、1R6G、1XZX、1Y0X、2J4A、2NLL、2PIN、3D57、3GWS、3IMY、3JZC、4ZO1识别号别名THRB;, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, TRbeta外部IDOMIM:190160 MGI:98743 HomoloGene:36025 GeneCards:THRB 相关疾病selective pituitary resistance to thyroid hormone、generalized resistance to thyroid hormone[1]为以下药物的标靶反三碘甲状腺原氨酸、替拉曲可、三碘甲腺原氨酸、左旋甲状腺素钠[2]基因位置(人类)染色体3号染色体[3]基因座3p24.2起始24,117,153 bp[3]终止24,495,756 bp[3]基因位置(小鼠)染色体小鼠14号染色体[4]基因座14|14 A1起始4,431,611 bp[4]终止4,809,435 bp[4]RNA表达模式查阅更多表达数据基因本体分子功能• sequence-specific DNA binding• transcription corepressor activity• 锌离子结合• 金属离子结合• steroid hormone receptor activity• 血浆蛋白结合• 酶结合• chromatin DNA binding• thyroid hormone binding• DNA结合转录因子活性• DNA结合• DNA-binding transcription factor activity, RNA polymerase II-specific• transcription cis-regulatory region binding• RNA polymerase II transcription regulatory region sequence-specific DNA binding• 转录因子结合• nuclear receptor coactivator activity• signaling receptor activity• nuclear receptor activity细胞组分• 核质• 细胞核• nuclear body• RNA polymerase II transcription regulator complex生物学过程• regulation of transcription, DNA-templated• regulation of heart contraction• female courtship behavior• regulation of transcription by RNA polymerase II• negative regulation of transcription by RNA polymerase II• 听觉• type I pneumocyte differentiation• negative regulation of female receptivity• animal organ morphogenesis• transcription initiation from RNA polymerase II promoter• negative regulation of transcription, DNA-templated• positive regulation of transcription by RNA polymerase II• steroid hormone mediated signaling pathway• intracellular receptor signaling pathway• transcription, DNA-templated• negative regulation of eye photoreceptor cell development• retinal cone cell development• retinal cone cell apoptotic process• multicellular organism development• hormone-mediated signaling pathway• 细胞分化• 甲状旁腺的发生• response to lipid• thyroid hormone mediated signaling pathwaySources:Amigo / QuickGO直系同源物种人类小鼠Entrez706821834EnsemblENSG00000151090ENSMUSG00000021779UniProtP10828P37242mRNA序列NM_000461NM_001128176NM_001128177NM_001252634NM_001354708NM_001354709NM_001354710NM_001354711NM_001354712NM_001354713NM_001354714NM_001354715NM_001374822NM_001374823NM_001374824NM_001374825NM_001374826NM_001374827NM_001113417NM_009380蛋白序列NP_000452NP_001121648NP_001121649NP_001239563NP_001341637NP_001341638NP_001341639NP_001341640NP_001341641NP_001341642NP_001341643NP_001341644NP_001361751NP_001361752NP_001361753NP_001361754NP_001361755NP_001361756NP_001106888NP_033406基因位置(UCSC)Chr 3: 24.12 – 24.5 MbChr 14: 4.43 – 4.81 MbPubMed查找[5][6]维基数据查看/编辑人类查看/编辑小鼠Close
甲状腺激素β受体(TR-β,或THR-β)也称为核受体亚家族1,A 组,成员2(NR1A2),是一种核受体蛋白,在人类中由THR-β基因编码。[7][8] Quick Facts 甲状腺激素β受体, 已知的结构 ...甲状腺激素β受体已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表1BSX、1N46、1NAX、1NQ0、1NQ1、1NQ2、1NUO、1Q4X、1R6G、1XZX、1Y0X、2J4A、2NLL、2PIN、3D57、3GWS、3IMY、3JZC、4ZO1识别号别名THRB;, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, TRbeta外部IDOMIM:190160 MGI:98743 HomoloGene:36025 GeneCards:THRB 相关疾病selective pituitary resistance to thyroid hormone、generalized resistance to thyroid hormone[1]为以下药物的标靶反三碘甲状腺原氨酸、替拉曲可、三碘甲腺原氨酸、左旋甲状腺素钠[2]基因位置(人类)染色体3号染色体[3]基因座3p24.2起始24,117,153 bp[3]终止24,495,756 bp[3]基因位置(小鼠)染色体小鼠14号染色体[4]基因座14|14 A1起始4,431,611 bp[4]终止4,809,435 bp[4]RNA表达模式查阅更多表达数据基因本体分子功能• sequence-specific DNA binding• transcription corepressor activity• 锌离子结合• 金属离子结合• steroid hormone receptor activity• 血浆蛋白结合• 酶结合• chromatin DNA binding• thyroid hormone binding• DNA结合转录因子活性• DNA结合• DNA-binding transcription factor activity, RNA polymerase II-specific• transcription cis-regulatory region binding• RNA polymerase II transcription regulatory region sequence-specific DNA binding• 转录因子结合• nuclear receptor coactivator activity• signaling receptor activity• nuclear receptor activity细胞组分• 核质• 细胞核• nuclear body• RNA polymerase II transcription regulator complex生物学过程• regulation of transcription, DNA-templated• regulation of heart contraction• female courtship behavior• regulation of transcription by RNA polymerase II• negative regulation of transcription by RNA polymerase II• 听觉• type I pneumocyte differentiation• negative regulation of female receptivity• animal organ morphogenesis• transcription initiation from RNA polymerase II promoter• negative regulation of transcription, DNA-templated• positive regulation of transcription by RNA polymerase II• steroid hormone mediated signaling pathway• intracellular receptor signaling pathway• transcription, DNA-templated• negative regulation of eye photoreceptor cell development• retinal cone cell development• retinal cone cell apoptotic process• multicellular organism development• hormone-mediated signaling pathway• 细胞分化• 甲状旁腺的发生• response to lipid• thyroid hormone mediated signaling pathwaySources:Amigo / QuickGO直系同源物种人类小鼠Entrez706821834EnsemblENSG00000151090ENSMUSG00000021779UniProtP10828P37242mRNA序列NM_000461NM_001128176NM_001128177NM_001252634NM_001354708NM_001354709NM_001354710NM_001354711NM_001354712NM_001354713NM_001354714NM_001354715NM_001374822NM_001374823NM_001374824NM_001374825NM_001374826NM_001374827NM_001113417NM_009380蛋白序列NP_000452NP_001121648NP_001121649NP_001239563NP_001341637NP_001341638NP_001341639NP_001341640NP_001341641NP_001341642NP_001341643NP_001341644NP_001361751NP_001361752NP_001361753NP_001361754NP_001361755NP_001361756NP_001106888NP_033406基因位置(UCSC)Chr 3: 24.12 – 24.5 MbChr 14: 4.43 – 4.81 MbPubMed查找[5][6]维基数据查看/编辑人类查看/编辑小鼠Close