甲状腺激素α受体位於17號人類染色體的基因 / 维基百科,自由的 encyclopedia 甲状腺激素α受体(THR-α,TR-α),也称:核受体家族1, A组, 成员1 (NR1A1),是一类核受体蛋白,在人类中由THR-α基因编码。[7][8][9] Quick Facts 甲状腺激素α受体, 已知的结构 ...甲状腺激素α受体已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表1NAV、2H77、2H79、3HZF、3ILZ、3JZB、4LNW、4LNX识别号别名THRA;, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha, thyroid hormone receptor alpha, TRalpha外部IDOMIM:190120 MGI:98742 HomoloGene:37747 GeneCards:THRA 相关疾病congenital nongoitrous hypothryoidism 6[1]为以下药物的标靶反三碘甲状腺原氨酸、替拉曲可、三碘甲腺原氨酸、左旋甲状腺素钠[2]基因位置(人类)染色体17号染色体[3]基因座17q21.1起始40,058,290 bp[3]终止40,093,867 bp[3]基因位置(小鼠)染色体小鼠11号染色体[4]基因座11 D|11 62.58 cM起始98,631,464 bp[4]终止98,659,832 bp[4]RNA表达模式查阅更多表达数据基因本体分子功能• transcription cis-regulatory region binding• 血浆蛋白结合• single-stranded RNA binding• 锌离子结合• chromatin DNA binding• nuclear receptor activity• steroid receptor RNA activator RNA binding• 转录因子结合• TBP-class protein binding• steroid hormone receptor activity• DNA结合• protein domain specific binding• sequence-specific DNA binding• 金属离子结合• DNA结合转录因子活性• thyroid hormone binding• DNA-binding transcription factor activity, RNA polymerase II-specific• 大分子复合物结合• RNA polymerase II transcription regulatory region sequence-specific DNA binding• nuclear receptor coactivator activity• signaling receptor activity细胞组分• 细胞质• 核质• 细胞核• 细胞质基质• RNA polymerase II transcription regulator complex生物学过程• regulation of transcription by RNA polymerase II• response to cold• cytoplasmic sequestering of transcription factor• hormone-mediated signaling pathway• regulation of thyroid hormone mediated signaling pathway• 甲状旁腺的发生• regulation of transcription, DNA-templated• 成骨作用• female courtship behavior• cartilage condensation• negative regulation of RNA polymerase II transcription preinitiation complex assembly• type I pneumocyte differentiation• transcription, DNA-templated• steroid hormone mediated signaling pathway• transcription by RNA polymerase II• regulation of lipid catabolic process• regulation of heart contraction• animal organ morphogenesis• positive regulation of female receptivity• 学习和记忆• regulation of myeloid cell apoptotic process• positive regulation of transcription by RNA polymerase II• transcription initiation from RNA polymerase II promoter• erythrocyte differentiation• negative regulation of DNA-templated transcription, initiation• positive regulation of myotube differentiation• negative regulation of transcription, DNA-templated• intracellular receptor signaling pathway• negative regulation of transcription by RNA polymerase II• thyroid hormone mediated signaling pathway• multicellular organism development• brain development• 细胞分化• response to lipid• positive regulation of cold-induced thermogenesisSources:Amigo / QuickGO直系同源物种人类小鼠Entrez706721833EnsemblENSG00000126351ENSMUSG00000058756UniProtP10827P63058mRNA序列NM_199334NM_001190918NM_001190919NM_003250NM_178060NM_001313983蛋白序列NP_001177847NP_001177848NP_003241NP_955366NP_001300912NP_835161基因位置(UCSC)Chr 17: 40.06 – 40.09 MbChr 11: 98.63 – 98.66 MbPubMed查找[5][6]维基数据查看/编辑人类查看/编辑小鼠Close
甲状腺激素α受体(THR-α,TR-α),也称:核受体家族1, A组, 成员1 (NR1A1),是一类核受体蛋白,在人类中由THR-α基因编码。[7][8][9] Quick Facts 甲状腺激素α受体, 已知的结构 ...甲状腺激素α受体已知的结构PDB直系同源搜索: PDBe RCSB PDBID列表1NAV、2H77、2H79、3HZF、3ILZ、3JZB、4LNW、4LNX识别号别名THRA;, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha, thyroid hormone receptor alpha, TRalpha外部IDOMIM:190120 MGI:98742 HomoloGene:37747 GeneCards:THRA 相关疾病congenital nongoitrous hypothryoidism 6[1]为以下药物的标靶反三碘甲状腺原氨酸、替拉曲可、三碘甲腺原氨酸、左旋甲状腺素钠[2]基因位置(人类)染色体17号染色体[3]基因座17q21.1起始40,058,290 bp[3]终止40,093,867 bp[3]基因位置(小鼠)染色体小鼠11号染色体[4]基因座11 D|11 62.58 cM起始98,631,464 bp[4]终止98,659,832 bp[4]RNA表达模式查阅更多表达数据基因本体分子功能• transcription cis-regulatory region binding• 血浆蛋白结合• single-stranded RNA binding• 锌离子结合• chromatin DNA binding• nuclear receptor activity• steroid receptor RNA activator RNA binding• 转录因子结合• TBP-class protein binding• steroid hormone receptor activity• DNA结合• protein domain specific binding• sequence-specific DNA binding• 金属离子结合• DNA结合转录因子活性• thyroid hormone binding• DNA-binding transcription factor activity, RNA polymerase II-specific• 大分子复合物结合• RNA polymerase II transcription regulatory region sequence-specific DNA binding• nuclear receptor coactivator activity• signaling receptor activity细胞组分• 细胞质• 核质• 细胞核• 细胞质基质• RNA polymerase II transcription regulator complex生物学过程• regulation of transcription by RNA polymerase II• response to cold• cytoplasmic sequestering of transcription factor• hormone-mediated signaling pathway• regulation of thyroid hormone mediated signaling pathway• 甲状旁腺的发生• regulation of transcription, DNA-templated• 成骨作用• female courtship behavior• cartilage condensation• negative regulation of RNA polymerase II transcription preinitiation complex assembly• type I pneumocyte differentiation• transcription, DNA-templated• steroid hormone mediated signaling pathway• transcription by RNA polymerase II• regulation of lipid catabolic process• regulation of heart contraction• animal organ morphogenesis• positive regulation of female receptivity• 学习和记忆• regulation of myeloid cell apoptotic process• positive regulation of transcription by RNA polymerase II• transcription initiation from RNA polymerase II promoter• erythrocyte differentiation• negative regulation of DNA-templated transcription, initiation• positive regulation of myotube differentiation• negative regulation of transcription, DNA-templated• intracellular receptor signaling pathway• negative regulation of transcription by RNA polymerase II• thyroid hormone mediated signaling pathway• multicellular organism development• brain development• 细胞分化• response to lipid• positive regulation of cold-induced thermogenesisSources:Amigo / QuickGO直系同源物种人类小鼠Entrez706721833EnsemblENSG00000126351ENSMUSG00000058756UniProtP10827P63058mRNA序列NM_199334NM_001190918NM_001190919NM_003250NM_178060NM_001313983蛋白序列NP_001177847NP_001177848NP_003241NP_955366NP_001300912NP_835161基因位置(UCSC)Chr 17: 40.06 – 40.09 MbChr 11: 98.63 – 98.66 MbPubMed查找[5][6]维基数据查看/编辑人类查看/编辑小鼠Close