帕扎克兰(INN:Pozanicline;开发代号:ABT-089)是一种含氮有机化合物,分子式C11H16N2O,是美国雅培公司研发的益智药和神经保护药。[1][2][3]
Quick Facts 识别信息, CAS号 ...
帕扎克兰 |
|
2-Methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine
|
CAS号 | 161417-03-4 Y |
---|
PubChem CID | |
---|
ChemSpider | |
---|
UNII | |
---|
CompTox Dashboard (EPA) | |
---|
|
化学式 | C11H16N2O |
---|
摩尔质量 | 192.26 g·mol−1 |
---|
3D模型(JSmol) | |
---|
CC1=C(C=CC=N1)OC[C@@H]2CCCN2
|
InChI=1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1 NKey:YRVIKLBSVVNSHF-JTQLQIEISA-N N
|
Close
Lin NH, Gunn DE, Ryther KB, Garvey DS, Donnelly-Roberts DL, Decker MW, et al. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. Journal of Medicinal Chemistry. January 1997, 40 (3): 385–90. PMID 9022806. doi:10.1021/jm960233u.
Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Xue IC, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. The Journal of Pharmacology and Experimental Therapeutics. October 1997, 283 (1): 235–46. PMID 9336329.
Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys. The Journal of Pharmacology and Experimental Therapeutics. October 1997, 283 (1): 247–58. PMID 9336330.