在酶学中,mRNA鸟苷酸转移酶(EC 2.7.7.50)是一种催化化学反应的酶。
- GTP + (5')ppPur-mRNA diphosphate + G(5')pppPur-mRNA
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因此,该酶的两个底物是GTP和(5')ppPur-mRNA,而其两个产物是二磷酸和G(5')pppPur-mRNA。该酶属于转移酶家族,特别是转移含磷的核苷酸基团的那些酶(核苷酸转移酶)。
该酶类别的系统名称是GTP:mRNA鸟苷酸转移酶。常用的其他名称包括mRNA加帽酶、mRNA鸟苷酸转移酶和Protein 2。
截至2007年底,该类酶已解析了5种结构,PDB登录号为1CKM、1CKN、1CKO、1P16和2C46。
- Ensinger MJ, Martin SA, Paoletti E, Moss B. Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus. Proc. Natl. Acad. Sci. U.S.A. 1975, 72 (7): 2525–9. Bibcode:1975PNAS...72.2525E. PMC 432801 . PMID 1058472. doi:10.1073/pnas.72.7.2525.
- Groner Y, Gilboa E, Aviv H. Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates. Biochemistry. 1978, 17 (6): 977–82. PMID 629955. doi:10.1021/bi00599a005.
- Itoh N, Yamada H, Kaziro Y, Mizumoto K. Messenger RNA guanylyltransferase from Saccharomyces cerevisiae Large scale purification, subunit functions, and subcellular localization. J. Biol. Chem. 1987, 262 (5): 1989–95. PMID 3029058.
- Martin SA, Moss B. Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions. J. Biol. Chem. 1975, 250 (24): 9330–5. PMID 1194287.
- Martin SA, Paoletti E, Moss B. Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions. J. Biol. Chem. 1975, 250 (24): 9322–9. PMID 1194286.