古尔德-雅各布斯反应(Gould–Jacobs reaction)是合成喹啉的方法。[1]
苯胺或其衍生物与乙氧基亚甲基丙二酸二乙酯反应,取代为烯胺。烯胺在加热时环化,然后再用氢氧化钠水解酯基,并脱羧,得到最终产物4-羟基喹啉。
例如用此反应合成4,7-二氯喹啉:[2]
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参考资料
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