DEDD

含死亡效应结构域蛋白（英语：Death effector domain containing protein）是人类中由DEDD基因编码的蛋白质。^[5][6][7]

DEDD
识别号
别名	DEDD；, CASP8IP1, DEDD1, DEFT, FLDED1, KE05, death effector domain containing
外部ID	OMIM：606841 MGI：1333874 HomoloGene：7980 GeneCards：DEDD
基因位置（人类） 染色体 1号染色体[1] 基因座 1q23.3 起始 161,120,974 bp[1] 终止 161,132,688 bp[1]
基因位置（小鼠） 染色体 小鼠1号染色体[2] 基因座 1 H3|1 79.34 cM 起始 171,156,713 bp[2] 终止 171,169,899 bp[2]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • 血浆蛋白结合 • DNA结合 细胞组分 • 细胞质 • 细胞核 • 核仁 生物学过程 • regulation of apoptotic process • regulation of transcription, DNA-templated • transcription, DNA-templated • 细胞凋亡 • 精子发生 • extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of protein catabolic process • 蜕膜化 • negative regulation of transcription of nucleolar large rRNA by RNA polymerase I Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	9191	21945
Ensembl	ENSG00000158796	ENSMUSG00000013973
UniProt	O75618	Q9Z1L3
mRNA​序列	​NM_001039711 ​NM_001039712 ​NM_004216 ​NM_032998 ​NM_001330765	NM_001128609 ​NM_011615 ​NM_001357550 ​NM_001357551 ​NM_001357552 ​NM_001357553
蛋白序列	NP_001034800 ​NP_001034801 ​NP_001317694 ​NP_127491	NP_001122081 ​NP_035745 ​NP_001344479 ​NP_001344480 ​NP_001344481 ​NP_001344482
基因位置​（UCSC）	Chr 1: 161.12 – 161.13 Mb	Chr 1: 171.16 – 171.17 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

功能

该基因编码含有死亡效应结构域（DED）的蛋白质。DED是程序性细胞死亡途径的衔接子、调节子和执行子共享的蛋白质相互作用域。该基因的过度表达被证明可诱导微弱的细胞凋亡。在刺激作用下，发现该蛋白从细胞质易位到细胞核，并与UBTF共定位在核仁中，UBTF是RNA聚合酶I转录所需的基础因子。该基因至少有三种编码相同蛋白质的转录变体。^[8]

相互作用

DEDD已被证明可以与以下基因产生相互作用：

• CFLAR^[9][10]
• 胱天蛋白酶8^[9][11][12]
• FADD^[5][10]

参考资料

1. GRCh38: Ensembl release 89: ENSG00000158796 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000013973 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Dec 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
6. Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. Dec 1998, 139 (12): 4839–48. PMID 9832420. doi:10.1210/endo.139.12.6335 .
7. Entrez Gene: DEDD death effector domain containing. [2024-03-15]. （原始内容存档于2010-12-05）.
8. ^ 引用错误：没有为名为entrez2的参考文献提供内容
9. Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. Apr 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
10. Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. Mar 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .
11. Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Oct 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
12. Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. Jan 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .

延伸阅读

• Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E. Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Int. J. Cancer. 2005, 115 (3): 412–8. PMID 15688372. doi:10.1002/ijc.20857 .
• Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .
• Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME. DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell Biol. 2002, 158 (6): 1051–66. PMC 2173221 . PMID 12235123. doi:10.1083/jcb.200112124.
• Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
• Schickling O, Stegh AH, Byrd J, Peter ME. Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ. 2002, 8 (12): 1157–68. PMID 11753564. doi:10.1038/sj.cdd.4400928 .
• Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .