4-甲氧基雌酮

4-甲氧基雌酮
	IUPAC名; (8R,9S,13S,14S)-3-Hydroxy-4-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
别名	4-ME1; 4-MeOE1; 4-MeO-E1; 4-Hydroxyestrone 4-methyl ether; 3-Hydroxy-4-methoxyestra-1,3,5(10)-trien-17-one
识别
CAS号	58562-33-7
PubChem	194066
ChemSpider	168393
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4OC)O;
ChEBI	136972
性质
化学式	C19H24O3
摩尔质量	300.39 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

4-甲氧基雌酮（英语：4-Methoxyestrone，缩写4-ME1）是一种天然内源性的甲氧基化的儿茶酚雌激素和雌酮的代谢产物，在体内通过儿茶酚-O-甲基转移酶（COMT）催化中间体 4-羟基雌酮生成^[1]^[2]^[3]，其雌激素活性近似雌酮和4-羟基雌酮^[4]。

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[1]
存档副本. [2021-01-28]. （原始内容存档于2017-01-01）.
[2]
Hemnes AR. Gender, Sex Hormones and Respiratory Disease: A Comprehensive Guide. Humana Press. 16 December 2015: 32–. ISBN 978-3-319-23998-9.
[3]
Lauritzen C, Studd JW. Current Management of the Menopause. CRC Press. 22 June 2005: 378–379. ISBN 978-0-203-48612-2.
[4]
Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. Journal of the Society for Gynecologic Investigation. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6.

参考资料

4-甲氧基雌酮

IUPAC名 (8R,9S,13S,14S)-3-Hydroxy-4-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
别名	4-ME1; 4-MeOE1; 4-MeO-E1; 4-Hydroxyestrone 4-methyl ether; 3-Hydroxy-4-methoxyestra-1,3,5(10)-trien-17-one
识别
CAS号	58562-33-7 ^Y
PubChem	194066
ChemSpider	168393
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4OC)O
ChEBI	136972
性质
化学式	C₁₉H₂₄O₃
摩尔质量	300.39 g·mol⁻¹
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。