25号美国国道（英语：U.S. Route 25）是一条南北方向的美国国道。该公路连接了佐治亚州格林县和肯塔基州卡温顿，全长750英里。
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| 道路信息 | |
| 管理方 | Georgia Department of Transportation[*]、Kentucky Transportation Cabinet[*]、Tennessee Department of Transportation[*] |
| 道路总长 | 750英里（1,210公里） |
| 公路系统 | |
外部链接
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