阿巴康唑

阿巴康唑（INN：albaconazole；开发代号：UR-9825）是一种实验性三唑类抗真菌药。^[1]它具有潜在的广谱活性，可能可以用于治疗南美锥虫病。^[2][3]它也被研究作为抗原虫剂（英语：Antiprotozoal）。^[2]

阿巴康唑

临床资料
ATC码	未分配
识别信息
IUPAC命名法 7-Chloro-3-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]quinazolin-4-one
CAS号	187949-02-6  Y
PubChem CID	208952
ChemSpider	181045 Y
UNII	YDW24Y8IAB
KEGG	D09702 Y
ChEMBL	ChEMBL298817 Y
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID3058244
ECHA InfoCard	100.170.829
化学信息
化学式	C20H16ClF2N5O2
摩尔质量	431.83 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES Fc1ccc(c(F)c1)[C@](O)([C@H](N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4
InChI InChI=1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 Y Key:UHIXWHUVLCAJQL-MPBGBICISA-N Y

参考资料

1. Albaconazole. Adis Insight. Springer Nature Switzerland AG.
2. Guedes, Paulo Marcos da Matta; Urbina, Julio A.; de Lana, Marta; Afonso, Luis C. C.; Veloso, Vanja M.; Tafuri, Washington L.; Machado-Coelho, George L. L.; Chiari, Egler; Bahia, Maria Terezinha. Activity of the New Triazole Derivative Albaconazole against Trypanosoma (Schizotrypanum) cruzi in Dog Hosts. Antimicrobial Agents and Chemotherapy. 2004-11, 48 (11). ISSN 0066-4804. PMID 15504854. doi:10.1128/AAC.48.11.4286-4292.2004.
3. Guillon, Rémi; Pagniez, Fabrice; Picot, Carine; Hédou, Damien; Tonnerre, Alain; Chosson, Elizabeth; Duflos, Muriel; Besson, Thierry; Logé, Cédric; Le Pape, Patrice. Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole. ACS Medicinal Chemistry Letters. 2013-01-17, 4 (2). ISSN 1948-5875. PMC 4027234 . PMID 24900660. doi:10.1021/ml300429p.