葡萄球菌黄素

葡萄球菌黄素
	IUPAC名; [(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-[[(12S)-12-methyltetradecanoyl]oxymethyl]oxan-2-yl](2E,4E,6E,8E,10E,12E,14E,16E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,4,6,8,10,12,14,16,18,22-decaenoate
识别
CAS号	71869-01-7 =
PubChem	24892781
ChemSpider	4947803
SMILES	O=C(O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO)\C(=C\C=C\C(C)(C\C=C\C=C(\C=C\C=C(\C=C\C=C(/C)CC\C=C(/C)C)C)C)C(\C=C/CCCCCCCC(C)CC)C=O)C;
ChEBI	71690
性质
化学式	C51H78O8
摩尔质量	819.16 g·mol−1
外观	金黄色物质
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

葡萄球菌黄素（英语：Staphyloxanthin）是一种由一些金黄色葡萄球菌菌种制造的类胡萝卜素。这种色素给了金黄色葡萄球菌它的颜色。

事实速览 葡萄球菌黄素, 识别 ...

关闭

葡萄球菌黄素在金黄色葡萄球菌的感染中扮演了重要的角色。作为一种抗氧化剂，它保护金黄色葡萄球菌免于被白细胞释放的活性氧杀死。^[2]

一些药物可以抑制金黄色葡萄球菌制造葡萄球菌黄素并且可以使金黄色葡萄球菌容易被抗生素杀灭。^[3]事实上，由于葡萄球菌黄素和人类胆固醇的合成有相似的步骤，所以降低胆固醇的药物和治疗方法也可以阻止细菌制造葡萄球菌黄素。^[4]

[1]
Pelz, Alexandra; Wieland, Karsten-Peter; Putzbach, Karsten; Hentschel, Petra; Albert, Klaus; Götz, Friedrich. Structure and Biosynthesis of Staphyloxanthin from Staphylococcus aureus. Journal of Biological Chemistry. 2005, 280 (37): 32493–32498. doi:10.1074/jbc.M505070200.
[2]
Clauditz, Alexandra; Resch, Alexandra; Wieland, Karsten-Peter; Peschel, Andreas; Götz, Friedrich. Staphyloxanthin Plays a Role in the Fitness of Staphylococcus aureus and Its Ability To Cope with Oxidative Stress. Infection and Immunity. 2006-08, 74 (8): 4950–4953 [2022-01-03]. ISSN 0019-9567. PMC 1539600 . PMID 16861688. doi:10.1128/IAI.00204-06. （原始内容存档于2022-01-03）（英语）.
[3]
Liu, George Y.; Essex, Anthony; Buchanan, John T.; Datta, Vivekanand; Hoffman, Hal M.; Bastian, John F.; Fierer, Joshua; Nizet, Victor. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. Journal of Experimental Medicine. 2005-07-18, 202 (2): 209–215 [2022-01-03]. ISSN 1540-9538. PMC 2213009 . PMID 16009720. doi:10.1084/jem.20050846. （原始内容存档于2022-03-16）（英语）.
[4]
Liu, Chia-I; Liu, George Y.; Song, Yongcheng; Yin, Fenglin; Hensler, Mary E.; Jeng, Wen-Yih; Nizet, Victor; Wang, Andrew H.-J.; Oldfield, Eric. A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence. Science. 2008-03-07, 319 (5868): 1391–1394 [2022-01-03]. ISSN 0036-8075. PMC 2747771 . PMID 18276850. doi:10.1126/science.1153018. （原始内容存档于2022-03-02）（英语）.

Remove ads

Staphyloxanthin on www.genome.jp （页面存档备份，存于互联网档案馆）（日语）

[1] [1]
Pelz, Alexandra; Wieland, Karsten-Peter; Putzbach, Karsten; Hentschel, Petra; Albert, Klaus; Götz, Friedrich. Structure and Biosynthesis of Staphyloxanthin from Staphylococcus aureus. Journal of Biological Chemistry. 2005, 280 (37): 32493–32498. doi:10.1074/jbc.M505070200.

[staphylotoxin-2] [2]
Clauditz, Alexandra; Resch, Alexandra; Wieland, Karsten-Peter; Peschel, Andreas; Götz, Friedrich. Staphyloxanthin Plays a Role in the Fitness of Staphylococcus aureus and Its Ability To Cope with Oxidative Stress. Infection and Immunity. 2006-08, 74 (8): 4950–4953 [2022-01-03]. ISSN 0019-9567. PMC 1539600 . PMID 16861688. doi:10.1128/IAI.00204-06. （原始内容存档于2022-01-03）（英语）.

[JExpMed2005-Liu-3] [3]
Liu, George Y.; Essex, Anthony; Buchanan, John T.; Datta, Vivekanand; Hoffman, Hal M.; Bastian, John F.; Fierer, Joshua; Nizet, Victor. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. Journal of Experimental Medicine. 2005-07-18, 202 (2): 209–215 [2022-01-03]. ISSN 1540-9538. PMC 2213009 . PMID 16009720. doi:10.1084/jem.20050846. （原始内容存档于2022-03-16）（英语）.

[Science2008-Liu-4] [4]
Liu, Chia-I; Liu, George Y.; Song, Yongcheng; Yin, Fenglin; Hensler, Mary E.; Jeng, Wen-Yih; Nizet, Victor; Wang, Andrew H.-J.; Oldfield, Eric. A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence. Science. 2008-03-07, 319 (5868): 1391–1394 [2022-01-03]. ISSN 0036-8075. PMC 2747771 . PMID 18276850. doi:10.1126/science.1153018. （原始内容存档于2022-03-02）（英语）.

[1]

[2]

[3]

[4]

葡萄球菌黄素

Wikiwand in your browser!

葡萄球菌黄素

Wikiwand in your browser!

在金黄色葡萄球菌内的作用

参考文献

参见

外部链接

葡萄球菌黄素

IUPAC名 [(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-[[(12S)-12-methyltetradecanoyl]oxymethyl]oxan-2-yl](2E,4E,6E,8E,10E,12E,14E,16E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,4,6,8,10,12,14,16,18,22-decaenoate
识别
CAS号	71869-01-7 ^Y=
PubChem	24892781
ChemSpider	4947803
SMILES	O=C(O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)CO)\C(=C\C=C\C(C)(C\C=C\C=C(\C=C\C=C(\C=C\C=C(/C)CC\C=C(/C)C)C)C)C(\C=C/CCCCCCCC(C)CC)C=O)C
ChEBI	71690
性质
化学式	C₅₁H₇₈O₈
摩尔质量	819.16 g·mol⁻¹
外观	金黄色物质^[1]
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。