莫克雌醇

莫克雌醇（英语：Moxestrol）是一种雌激素类药物，商品名Surestryl，化学名为11β-甲氧基乙炔雌二醇，与RU-16117是11β-差向异构体，用于治疗更年期综合症和月经失调，在欧洲有上市销售^{[3][4][2][5][6]}。

莫克雌醇

临床资料
商品名（英语：Drug nomenclature）	Surestryl
其他名称	R-2858, RU-2858, NSC-118191; 11β-Methoxy-17α-ethynylestradiol; 11β-MeO-EE 11β-Methoxy-17α-ethynylestra-1,3,5(10)-triene-3,17β-diol
怀孕分级	X (Contraindicated)
给药途径	口服
药物类别（英语：Drug class）	Estrogen; Estrogen ether
ATC码	G03CB04 (WHO)
法律规范状态
法律规范	处方药（℞-only）
药物动力学数据
生物利用度	33%[1]
血浆蛋白结合率	Minimal[1]
药物代谢	Liver[2]
生物半衰期	8.2 hours[1]
识别信息
IUPAC命名法 (8S,9S,11S,13S,14S,17R)-17-ethynyl-11-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
CAS号	34816-55-2  Y
PubChem CID	11954041
ChemSpider	10128336
UNII	6923NT44OW
KEGG	C14757
ChEBI	CHEBI:34857
ChEMBL	ChEMBL1628161
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID8022375
化学信息
化学式	C21H26O3
摩尔质量	326.44 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES CC12CC(C3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O)OC
InChI InChI=1S/C21H26O3/c1-4-21(23)10-9-17-16-7-5-13-11-14(22)6-8-15(13)19(16)18(24-3)12-20(17,21)2/h1,6,8,11,16-19,22-23H,5,7,9-10,12H2,2-3H3/t16-,17-,18-,19+,20-,21-/m0/s1 Key:MTMZZIPTQITGCY-OLGWUGKESA-N

参考资料

1. Salmon, J.; Coussediere, D.; Cousty, C.; Raynaud, J.P. Pharmacokinetics and metabolism of moxestrol in animals—rat, dog and monkey. Journal of Steroid Biochemistry. 1983, 19 (2): 1223–1234. ISSN 0022-4731. PMID 6887930. doi:10.1016/0022-4731(83)90421-1.
2. Jonathan J. Li; Satyabrata Nandi; Sara A. Li. Hormonal Carcinogenesis: Proceedings of the First International Symposium. Springer Science & Business Media. 6 December 2012: 184– [2021-11-30]. ISBN 978-1-4613-9208-8. （原始内容存档于2021-11-30）.
3. J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 841– [2021-11-30]. ISBN 978-1-4757-2085-3. （原始内容存档于2021-11-30）.
4. Dr. Ian Morton; I.K. Morton; Judith M. Hall. Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 31 October 1999: 186– [2021-11-30]. ISBN 978-0-7514-0499-9. （原始内容存档于2021-11-30）.
5. Adrain D. Nunn. Radiopharmaceuticals: Chemistry and Pharmacology. CRC Press. 19 June 1992: 342– [2021-11-30]. ISBN 978-0-8247-8624-3. （原始内容存档于2021-11-30）.
6. William Martindale; Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences. The Extra Pharmacopoeia. Pharmaceutical Press. 1993: 1188 [2021-11-30]. ISBN 978-0-85369-300-0. （原始内容存档于2021-11-30）. Moxestrol is a synthetic oestrogen with actions and uses similar to thosre described for the oestrogens in general. Moxestrol is reponed to have a prolonged duration of action. It has been given by mouth in the treatment of menopausal, postmenopausal, and menstrual symptoms. Dose have ranged from 50 to 100 µg weekly for long-term therapy to 25 to 250 µg daily for short-term use.