细胞色素b5

细胞色素b5^[1]（英语：Cytochrome b5）是一种存在于动物、植物、真菌以及紫色光养菌中遍及的电子传递血红素蛋白。该细胞色素于微粒体及线粒体中的变体是与膜相结合的，而细菌、红细胞以及其他动物组织中的却是水溶性的。

细胞色素b5
结合了血红素的大鼠细胞色素b5
识别
符号	CYB5A
替换符号	CYB5
Entrez	1528
HUGO	2570
OMIM	250790
PDB	1JEX
RefSeq	NM_001914
UniProt	P00167
其他资料
基因座	18 q23

细胞色素b5
鉴定
标志	Cyt_B5
Pfam	PF00173（旧版）
InterPro（英语：InterPro）	IPR001199
PROSITE（英语：PROSITE）	PDOC00170
现有可用的蛋白结构： Pfam 结构（旧版） / ECOD PDB RCSB PDB; PDBe; PDBj PDBsum（英语：PDBsum） 结构概要 PDB 1aqa, 1aw3, 1awp, 1axx, 1b5a, 1b5b, 1b5m, 1bfx, 1blv, 1cxy, 1cyo, 1do9, 1ehb, 1es1, 1eue, 1f03, 1f04, 1fcb, 1hko, 1i5u, 1i87, 1i8c, 1ib7, 1icc, 1iet, 1ieu, 1j03, 1j0q, 1jex, 1kbi, 1kbj, 1lco, 1ldc, 1lj0, 1lqx, 1lr6, 1ltd, 1m20, 1m2i, 1m2m, 1m59, 1mj4, 1mny, 1nx7, 1qcw, 1sh4, 1sox, 1sze, 1szf, 1szg, 1t0g, 1u9m, 1u9u, 1x3x, 2axx, 2i89, 2ibj, 2oz0

参考文献

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• Lederer, F. The cytochrome b₅-fold: an adaptable module. Biochimie. 1994, 76 (7): 674–692. PMID 7893819. doi:10.1016/0300-9084(94)90144-9.
• Napier, J.A., Michaelson, L.V. and Sayanova, O. The role of cytochrome b₅ fusion desaturases in the synthesis of polyunsaturated fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2003, 68 (2): 135–143. PMID 12538077. doi:10.1016/S0952-3278(02)00263-6.
• Rivera, M., Barillas-Mury, C., Christensen, K.A., Little, J.W., Wells, M.A. and Walker, F.A. Gene synthesis, bacterial expression, and ¹H NMR spectroscopic studies of the rat outer mitochondrial membrane cytochrome b₅. Biochemistry. 1992, 31 (48): 12233–12240. PMID 1333795. doi:10.1021/bi00163a037.
• Schenkman, J.B. and Jansson, I. The many roles of cytochrome b₅. Pharmacol. Ther. 2003, 97 (2): 139–152. PMID 12559387. doi:10.1016/S0163-7258(02)00327-3.

外部链接

• PDB 1B5A - Solution structure of rat cytochrome b₅ (form A)
• PDB 1B5B - Solution structure of rat cytochrome b₅ (form B)
• PDB 1CXY - X-ray structure of cytochrome b₅₅₈ from Ectothiorhodospira vacuolata
• OMIM 250790 - Methemoglobinemia due to deficiency of cytochrome b₅