德萨瓜德罗河（西班牙语：Río Desaguadero、奇楚瓦语：Huchusuma mayu）是南美洲的河流，位于秘鲁和玻利维亚，发源自的的喀喀湖南部，约5%湖水经河道往南流往乌鲁乌鲁湖和波波湖。[1]
在附近居住的美洲原住民靠德萨瓜德罗河维持生活，而河道只能让小船经过。
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