美国毒蜥(学名:Heloderma suspectum)亦称为希拉毒蜥或钝尾毒蜥,英文有“Gila Monster”之称,因为希拉河盆地(Gila River Basin)而得名。美国毒蜥是世界上仅有的三种毒蜥的其中一种〈另一种是墨西哥毒蜥和危地马拉珠毒蜥〉,主要就分布在美国西部,南部各州,以莫哈维沙漠(Mojave)为中心,延伸进入墨西哥,
美国毒蜥有两个亚种:分布区北部的黑带美国毒蜥(H. s. cinctum)和分布区南部的网纹美国毒蜥(H. s. suspectum)。
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美国毒蜥以小型鸟类,爬虫类卵为主食。
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