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嘉靖三十二年(1553年)二月,李氏嫁给朱载坖,封为裕王妃。生长子朱翊鉽(5岁夭折)、次子朱翊铃(1岁夭折)和长女(名不详,夭折)。嘉靖三十七年(1558年)四月,王妃李氏逝世,年仅20多岁。朱载坖即位后,亲定谥号,追谥李氏为孝懿皇后,朱翊鉽为宪怀太子,朱翊铃为靖悼王,长女为蓬莱公主,将李氏的父亲李铭封为德平伯。明神宗即位后,追尊这位从未见面的嫡母为孝懿贞惠顺哲恭仁俪天襄圣庄皇后。
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