阿片样肽受体

阿片样肽受体或阿片类受体、阿片受体（英语：Opioid receptors）是一类以阿片样肽为配体的G蛋白偶联受体^[1]^[2]^[3]。内源性类阿片物质包括强啡肽、脑啡肽（英语：enkephalin）、内啡肽、endomorphin（英语：endomorphin）和nociceptin（英语：nociceptin）。阿片样肽受体与生长抑素受体（SSTRs）有约40%的相似性。阿片受体广泛分布于大脑，且在脊髓与消化道中也有发现。

[1]
Dhawan BN, Cesselin F, Raghubir R, Reisine T, Bradley PB, Portoghese PS, Hamon M. International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol. Rev. December 1996, 48 (4): 567–92. PMID 8981566.
[2]
Janecka A, Fichna J, Janecki T. Opioid receptors and their ligands. Curr Top Med Chem. 2004, 4 (1): 1–17. PMID 14754373.
[3]
Waldhoer M, Bartlett SE, Whistler JL. Opioid receptors. Annu. Rev. Biochem. 2004, 73: 953–90. PMID 15189164. doi:10.1146/annurev.biochem.73.011303.073940.

医学主题词表（MeSH）：Opioid+Receptors
Opioid Receptors. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始内容存档于2021-01-18）.
Corbett A, McKnight S, Henderson G. Opioid Receptors. BLTC Research. [2008-03-21]. （原始内容存档于2021-03-14）.
Lomize A, Lomize M, Pogozheva I. Orientations of Proteins in Membranes (OPM) database. University of Michigan. [2008-03-21]. （原始内容存档于2014-01-03）.
- Mu-opioid receptor model (inactive state) with antagonist. [2008-03-21]. （原始内容存档于2021-01-28）.
- Mu-opioid receptor model in active state with agonist. [2008-03-21]. （原始内容存档于2021-01-28）.
Guzman, F. Video lectures on opioid receptors. Pharmacology Corner. [2012-07-30]. （原始内容存档于2013-12-29）.

参考文献