布雷非德菌素A(英语:Brefeldin A)是一种大环内酯类抗生素,由布雷正青霉菌(Penicillium brefeldianum)等真菌组织产生[1]。布雷非德菌素A能通过阻止COPI被膜小泡的形成来抑制从内质网到高尔基体的蛋白质转运[2]。布雷非德菌素A最初被当做抗病毒药物分离出来[3],但现今的主要作用是在细胞生物学中研究蛋白质的转运。
布雷非德菌素A | |
---|---|
IUPAC名 (1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one | |
别名 | γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone |
识别 | |
CAS号 | 20350-15-6 |
PubChem | 5287620 |
ChemSpider | 4449949 |
SMILES |
|
InChI |
|
InChIKey | KQNZDYYTLMIZCT-KQPMLPITBH |
ChEBI | 48080 |
DrugBank | DB07348 |
性质 | |
化学式 | C16H24O4 |
摩尔质量 | 280.36 g·mol−1 |
外观 | White to off-white crystalline powder |
熔点 | 204.5 °C(478 K) |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
物理性质
生物学效应
参考文献
外部链接
Wikiwand in your browser!
Seamless Wikipedia browsing. On steroids.
Every time you click a link to Wikipedia, Wiktionary or Wikiquote in your browser's search results, it will show the modern Wikiwand interface.
Wikiwand extension is a five stars, simple, with minimum permission required to keep your browsing private, safe and transparent.