崔涓在大中四年（850年）进士擢第。他性情开敏。担任杭州刺史，没有全部认识属下卒史，于是用纸将他们的姓名写下傅在襟上，过前一看，后来数百人呼名无误。乾符初年，崔涓镇江陵为荆南节度使，辟王荛为从事。官至御史大夫。其子崔仁鲁，字化元；崔仁矩；崔仁宝，字国华。
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