南天竹啡碱(英语:Nantenine)是一种在南天竹[1]和一些紫堇属植物中发现的生物碱。[2]它是α1-肾上腺素能受体[3]和血清素5-HT2A受体的拮抗剂,[4]可阻断MDMA对动物的行为和生理作用。[5]
Quick Facts 临床资料, ATC码 ...
南天竹啡碱 |
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ATC码 | |
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(S)-1,2-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-benzo[de][1,3]benzodioxolo[5,6-g]quinoline
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CAS号 | 2565-01-7 Y |
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PubChem CID | |
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UNII | |
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CompTox Dashboard (EPA) | |
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化学式 | C20H21NO4 |
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摩尔质量 | 339.39 g·mol−1 |
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3D模型(JSmol) | |
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CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC5=C(C=C43)OCO5)OC)OC
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InChI=1S/C20H21NO4/c1-21-5-4-11-7-17(22-2)20(23-3)19-13-9-16-15(24-10-25-16)8-12(13)6-14(21)18(11)19/h7-9,14H,4-6,10H2,1-3H3/t14-/m0/s1 NKey:WSVWKHTVFGTTKJ-AWEZNQCLSA-N N
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Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Ohizumi Y. Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity. European Journal of Pharmacology. February 2002, 437 (3): 173–8. PMID 11890906. doi:10.1016/S0014-2999(02)01303-1.
Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH. Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. Psychopharmacology. May 2004, 173 (3–4): 270–7. PMID 14740148. S2CID 8425621. doi:10.1007/s00213-003-1741-2. hdl:2027.42/46360 .
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