CDKN1A (англ. Cyclin dependent kinase inhibitor 1A) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 164 амінокислот, а молекулярна маса — 18 119[4].
Послідовність амінокислот
10 | | 20 | | 30 | | 40 | | 50 |
MSEPAGDVRQ | | NPCGSKACRR | | LFGPVDSEQL | | SRDCDALMAG | | CIQEARERWN |
FDFVTETPLE | | GDFAWERVRG | | LGLPKLYLPT | | GPRRGRDELG | | GGRRPGTSPA |
LLQGTAEEDH | | VDLSLSCTLV | | PRSGEQAEGS | | PGGPGDSQGR | | KRRQTSMTDF |
YHSKRRLIFS | | KRKP |
Коротка інформація Наявні структури, PDB ...
CDKN1A
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Ідентифікатори |
Символи |
CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A |
Зовнішні ІД |
OMIM: 116899 MGI: 104556 HomoloGene: 333 GeneCards: CDKN1A
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Онтологія гена |
Молекулярна функція |
• зв'язування з іоном металу • GO:0001948, GO:0016582 protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • ubiquitin protein ligase binding • cyclin binding • cyclin-dependent protein kinase activating kinase activity • cyclin-dependent protein serine/threonine kinase activity • protein kinase inhibitor activity • protein kinase binding • GO:0032403 protein-containing complex binding
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Клітинна компонента |
• цитоплазма • гіалоплазма • cyclin-dependent protein kinase holoenzyme complex • PCNA-p21 complex • perinuclear region of cytoplasm • клітинне ядро • нуклеоплазма • ядерце • ядерні тільця • GO:0009327 protein-containing complex
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Біологічний процес |
• cellular response to extracellular stimulus • signal transduction by p53 class mediator • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • cellular response to heat • regulation of cyclin-dependent protein serine/threonine kinase activity • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of cell death • GO:1904578 response to organic cyclic compound • negative regulation of cyclin-dependent protein serine/threonine kinase activity • stress-induced premature senescence • positive regulation of fibroblast proliferation • replicative senescence • response to hyperoxia • response to corticosterone • cellular response to amino acid starvation • positive regulation of programmed cell death • negative regulation of apoptotic process • response to glucocorticoid • response to arsenic-containing substance • regulation of DNA biosynthetic process • response to organic substance • negative regulation of gene expression • cellular response to DNA damage stimulus • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • regulation of cell cycle • intrinsic apoptotic signaling pathway • клітинне старіння • positive regulation of reactive oxygen species metabolic process • cellular response to UV-B • G2/M transition of mitotic cell cycle • positive regulation of B cell proliferation • negative regulation of cell growth • response to organonitrogen compound • animal organ regeneration • regulation of mitotic cell cycle • intestinal epithelial cell maturation • cellular response to ionizing radiation • клітинний цикл • Ras protein signal transduction • negative regulation of phosphorylation • response to toxic substance • response to UV • response to X-ray • negative regulation of cell population proliferation • protein stabilization • positive regulation of cyclin-dependent protein kinase activity • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of protein kinase activity • cellular response to gamma radiation • negative regulation of cyclin-dependent protein kinase activity • transcription initiation from RNA polymerase II promoter • G1/S transition of mitotic cell cycle • cytokine-mediated signaling pathway • negative regulation of vascular associated smooth muscle cell proliferation
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних
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Ортологи |
Види |
Людина |
Миша |
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Entrez | |
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Ensembl |
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UniProt |
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RefSeq (мРНК) |
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RefSeq (білок) |
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Локус (UCSC) |
Хр. 6: 36.68 – 36.69 Mb |
Хр. 17: 29.31 – 29.32 Mb |
PubMed search |
[1] |
[2]
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Вікідані |
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Закрити
Кодований геном білок за функцією належить до фосфопротеїнів.
Задіяний у таких біологічних процесах, як клітинний цикл, ацетилювання.
Білок має сайт для зв'язування з іонами металів, іоном цинку.
Локалізований у цитоплазмі, ядрі.
- Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75: 805—816. PMID 8242751 DOI:10.1016/0092-8674(93)90499-G
- Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. (1994). Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211: 90—98. PMID 8125163 DOI:10.1006/excr.1994.1063
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Scott M.T., Morrice N., Ball K.L. (2000). Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding. J. Biol. Chem. 275: 11529—11537. PMID 10753973 DOI:10.1074/jbc.275.15.11529
- Coulombe P., Rodier G., Bonneil E., Thibault P., Meloche S. (2004). N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Mol. Cell. Biol. 24: 6140—6150. PMID 15226418 DOI:10.1128/MCB.24.14.6140-6150.2004
- Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. (2006). A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat. Biotechnol. 24: 1285—1292. PMID 16964243 DOI:10.1038/nbt1240