Prostaglandinski E receptor 3 (EP3) je prostaglandinski receptor, kodiran genom.[1]
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Затвори
Ovaj protein je član familije G protein spregnutih receptora. On je jedan od četiri receptora identifikovana za prostaglandin E2 (PGE2). Ovaj receptor ima mnoštvo bioloških funkcija, što obuhvata varenje, nervni sistem, bubrežnu reapsorpciju, i aktivnosti materičnih kontrakcija. U stomaku, on inhibira lučenje želudačne kiseline.
Ispitivanja na miševima sugeriraju da ovaj receptor takođe posreduje odgovor na adrenokortikotropni hormon kao i formiranje groznice.
Više alternativno splajsovanih transkriptnih varijanti kodira osam distinktnih izoformi.[1]
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