Orotat fosforiboziltransferaza

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PMC	članci
PubMed	članci
NCBI	proteini

Orotat fosforiboziltransferaza
Orotat fosforiboziltransferaza
Identifikatori
EC broj	2.4.2.10
CAS broj	9030-25-5
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Orotat fosforiboziltransferaza (EC 2.4.2.10, orotidilna kiselina fosforilaza, orotidin-5'-fosfat pirofosforilaza, OPRTaze, orotat fosforibozil pirofosfat transferaza, orotinsko kiselinska fosforiboziltransferaza, orotidin 5'-monofosfatna pirofosforilaza, orotidin monofosfatna pirofosforilaza, orotidinska fosforiboziltransferaza, orotidilatna fosforiboziltransferaza, orotidilatna pirofosforilaza, orotidilno kiselinska pirofosforilaza, orotidilna fosforilaza, orotidilna pirofosforilaza) je enzim sa sistematskim imenom orotidin-5'-fosfat:difosfat fosfo-alfa--ribozil-transferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

orotidin 5'-fosfat + difosfat

\rightleftharpoons

orotat + 5-fosfo-alfa--riboza 1-difosfat

Кратке чињенице Identifikatori, EC broj ...

Затвори

Enzim iz viših eukariota takođe katalizuje reakcije enzima EC 4.1.1.23, orotidin-5'-fosfat dekarboksilaza.

Reference

[1]
Jones, M.E., Kavipurapu, P.R. and Traut, T.W. (1978). „Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)”. Methods Enzymol. 51: 155—167. PMID 692383.
[2]
Lieberman, I., Kornberg, A. and Simms, E.S. (1955). „Enzymatic synthesis of pyrimidine nucleotides. Orotidine-5′-phosphate and uridine-5′-phosphate”. J. Biol. Chem. 215: 403—415. PMID 14392174.
[3]
McClard, R.W., Black, M.J., Livingstone, L.R. and Jones, M.E. (1980). „Isolation and initial characterization of the single polypeptide that synthesizes uridine 5′-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5′-monophosphate synthase”. Biochemistry. 19: 4699—4706. PMID 6893554.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Orotate+phosphoribosyltransferase на ()

[1] [1]
Jones, M.E., Kavipurapu, P.R. and Traut, T.W. (1978). „Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)”. Methods Enzymol. 51: 155—167. PMID 692383.

[2] [2]
Lieberman, I., Kornberg, A. and Simms, E.S. (1955). „Enzymatic synthesis of pyrimidine nucleotides. Orotidine-5′-phosphate and uridine-5′-phosphate”. J. Biol. Chem. 215: 403—415. PMID 14392174.

[3] [3]
McClard, R.W., Black, M.J., Livingstone, L.R. and Jones, M.E. (1980). „Isolation and initial characterization of the single polypeptide that synthesizes uridine 5′-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5′-monophosphate synthase”. Biochemistry. 19: 4699—4706. PMID 6893554.

[1]

[2]

[3]