1549
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1549 (MDXLIX) was a common year starting on Tuesday of the Julian calendar, the 1549th year of the Common Era (CE) and Anno Domini (AD) designations, the 549th year of the 2nd millennium, the 49th year of the 16th century, and the 10th and last year of the 1540s decade. As of the start of 1549, the Gregorian calendar was 10 days ahead of the Julian calendar, which was the dominant calendar of the time.

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Events
Births
- Maria Holl (d. 1634), German woman accused of witchcraft
- 30 July – Ferdinando I de' Medici, Grand Duke of Tuscany (d. 17 February 1609)
Deaths
- 10 November – Pope Paul III (b. 29 February 1468), 221st Pope of the Roman Catholic Church
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