The 1500s was a decade that started on 1 January 1500 and ended on 31 December 1509.
It is distinct from the decade known as the 151th decade which began on January 1, 1501. and ended on December 31, 1510.
| Millennium: | 2nd millennium |
| Centuries: | 15th century – 16th century – 17th century |
| Decades: | 1470s 1480s 1490s – 1500s – 1510s 1520s 1530s |
| Years: | 1500 1501 1502 1503 1504 1505 1506 1507 1508 1509 |
| Categories: | Births – Deaths – Architecture Establishments – Disestablishments |
- People begin to make cutlery in Sheffield, England.
- Leonardo da Vinci paints the Mona Lisa
- Spanish arrive in present-day Gulf of Mexico
- Portuguese navigator Pedro Álvares Cabral officially discovers Brazil and claims the land for Portugal.
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