Koagulacioni faktor Xa

Koagulacioni faktor Xa (EC 3.4.21.6, trombokinaza, protrombaza, protrombinaza, aktivirani krvno-koagulacioni faktor X, autoprotrombinska C, tromboplastin, plazmični tromboplastin, faktor Xa, aktivirani Stjuart-Prauer faktor, aktivirani faktor X) je enzim.^{[1][2][3][4][5][6]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Selektivno razlaganje Arg-Thr i zatim Arg-Ile veza u protrombinu čime se formira trombin

Koagulacioni faktor Xa
Identifikatori
EC broj	3.4.21.6
CAS broj	2594078
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Ovaj krvno koagulacioni faktor se formira iz proenzima faktor X putem ograničene proteolize.

Reference

1. Fujikawa, K. and Davie, E.W. (1976). „Bovine factor X (Stuart factor)”. Methods Enzymol. 45: 89-95. PMID 1012041.
2. Jesty, J. and Nemerson, Y. (1976). „The activation of bovine coagulation factor X”. Methods Enzymol. 45: 95-107. PMID 1012042.
3. Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. (1979). „The role of serine proteases in the blood coagulation cascade”. Adv. Enzymol. 48: 277-318. PMID 367103.
4. Jackson, C.M. and Nemerson, Y. (1980). „Blood coagulation”. Annu. Rev. Biochem. 49: 765-811. PMID 6996572.
5. McMullen, B.A., Fujikawa, K., Kisiel, W., Sasagawa, T., Howald, W.N., Kwa, E.Y. and Weinstein, B. (1983). „Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as β-hydroxyaspartic acid”. Biochemistry 22: 2875-2884. PMID 6871167.
6. Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry 23: 644-650. PMID 6370301.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

• MeSH Coagulation+factor+Xa