Orotidin-5'-fosfatna dekarboksilaza

Orotidin-5'-fosfatna dekarboksilaza (EC 4.1.1.23, orotidin-5'-monofosfatna dekarboksilaza, orotodilatna dekarboksilaza, orotidin fosfatna dekarboksilaza, OMP dekarboksilaza, orotat monofosfatna dekarboksilaza, orotidin monofosfatna dekarboksilaza, orotidin fosfatna dekarboksilaza, OMP-DC, orotatska dekarboksilaza, orotidin 5'-fosfatna dekarboksilaza, orotidilna dekarboksilaza, orotidilno kiselinska dekarboksilaza, orotodilatna dekarboksilaza, ODCaza, orotinska dekarboksilaza, orotidin-5'-fosfatna karboksi-lijaza) je enzim sa sistematskim imenom orotidin-5'-fosfat karboksi-lijaza (formira UMP).^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

orotidin 5'-fosfat ${\displaystyle \rightleftharpoons }$ UMP + CO₂

Orotidin-5'-fosfatna dekarboksilaza
Identifikatori
EC broj	4.1.1.23
CAS broj	9024-62-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Ovaj enzim viših eukariota je identičan sa EC 2.4.2.10, orotat fosforiboziltransferazom.

Reference

1. Jones, M.E., Kavipurapu, P.R. and Traut, T.W. (1978). „Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)”. Methods Enzymol. 51: 155-167. PMID 692383.
2. Lieberman, I., Kornberg, A. and Simms, E.S. (1955). „Enzymatic synthesis of pyrimidine nucleotides. Orotidine-5′-phosphate and uridine-5′-phosphate”. J. Biol. Chem. 215: 403-415. PMID 14392174.
3. McClard, R.W., Black, M.J., Livingstone, L.R. and Jones, M.E. (1980). „Isolation and initial characterization of the single polypeptide that synthesizes uridine 5′-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5′-monophosphate synthase”. Biochemistry 19: 4699-4706. PMID 6893554.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

• MeSH Orotidine-5'-phosphate+decarboxylase