Moždani natriuretski peptid

Moždani natriuretski peptid (osnovni natriuretski peptid, B-tip natriuretskog peptida, BNP, GC-B) je 32 aminokiseline dug polipeptid koji izlučuju srčane komore u odgovoru na prekomerno istezanje ćelija srčanog mišića (kardiomioccta). Oslobađanje BNP-a je modulisano jonima kalcijuma.^[1] BNP se naziva moždanim peptidom jer je originalno ekstrahovan iz svinjskog mozga. Kod ljud ovaj hormon uglavnom proizvode srčane komore.

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Natriuretski peptid B
Dostupne strukture
1YK1, 3N56
Identifikatori
Simboli	NPPB; BNP
Vanjski ID	OMIM: 600295 HomoloGene: 81698 GeneCards: NPPB Gene
Ontologija gena Molekularna funkcija • receptorsko vezivanje • hormonska aktivnost • aktivnost diuretiskog hormona Celularna komponenta • ekstracelularni region • ekstracelularni prostor • nukleus Biološki proces • response to hipoksiju • cGMP biosintetički proces • inflamatorni respons
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	4879	n/a
Ensembl	ENSG00000120937	n/a
UniProt	P16860	n/a
RefSeq (mRNA)	NM_002521.2	n/a
RefSeq (protein)	NP_002512.1	n/a
Lokacija (UCSC)	Chr 1: 11.92 - 11.92 Mb	n/a
PubMed pretraga		n/a

BNP se izlučuje zajedno sa 76 aminokiselina dugim N-terminalnim fragmentom (NT-proBNP) koji je biološki neaktivan. BNP se vezuje za i aktivira receptore atrijalnog natriuretskog faktora receptors NPRA, i manjoj meri NPRB, na sličan način kao i atrijalni natriuretski peptid (ANP) ali sa 10 puta manjim afinitetom. Biološki poluživot BNP-a je dva puta duži ANP, dok je poluživot NT-proBNP peptida još duži. It tog razloga ti peptidi su bolja meta za dijagnostičko testiranje krvi

Reference

1. Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1

Literatura

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• Seilhamer JJ, Arfsten A, Miller JA, et al. (1990). „Human and canine gene homologs of porcine brain natriuretic peptide”. Biochem. Biophys. Res. Commun. 165 (2): 650–8. DOI:10.1016/S0006-291X(89)80015-4. PMID 2597152.
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Povezano

• Atrijalni natriuretski peptid
• C-tip natriuretskog peptida

Vanjske veze

• MeSH Brain+Natriuretic+Peptide