Faktor licenciranja DNK replikacije MCM7

Faktor licenciranja DNK replikacije MCM7 je protein koji je kod ljudi kodiran MCM7 genom.^[1]

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Minichromosome maintenance complex component 7
Identifikatori
Simboli	MCM7; CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104
Vanjski ID	OMIM: 600592 MGI: 1298398 HomoloGene: 4323 GeneCards: MCM7 Gene
EC broj	3.6.4.12
Ontologija gena Molekulska funkcija • DNK vezivanje • aktivnost DNK helikaze • proteinsko vezivanje Ćelijska komponenta • nukleus • nukleoplazma • nukleolus Biološki proces • G1/S tranzicija mitotičkog ćelijskog ciklusa • mitotički ćelijski ciklus • DNK replikacija
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	4176	17220
Ensembl	ENSG00000166508	ENSMUSG00000029730
UniProt	P33993	Q61881
Ref. Sekv. (iRNK)	NM_001278595	NM_008568
Ref. Sekv. (protein)	NP_001265524	NP_032594
Lokacija (UCSC)	Chr 7: 99.69 - 99.7 Mb	Chr 5: 138.16 - 138.17 Mb
PubMed pretraga

Protein kodiran ovim genom je jedan od visoko konzerviranih proteina mini-hromozomskog održavanja (MCM) koji su esencijalni za inicijaciju replikacije eukariotskog genoma. Heksamerni proteinski kompleks formiran od MCM proteina je ključna komponenta prireplikacionog kompleksa (pre-RC) i može da učestuje u formiranju replikacionih viljuški i regrutovanju drugih proteina vezanih za DNK replikaciju. MCM kompleks se sastoji od ovog proteina i MCM2, dok 4 i 6 proteini poseduju DNK helikaznu aktivnost, i mogu da deluju kao enzimi DNK odmotavanja. Utvrđeno je da je ciklin D1-zavisna kinaza, CDK4, asocirana sa ovim proteinom, i da može da reguliše vezivanje ovog proteina sa proteinom supresije tumora RB1/RB. Poznate su alternativno splajsovane transkriptne varijante koje kodiraju distinktne izoforme.^[2]

Povezano

• Održavanje minihromozoma

Interakcije

MCM7 formira interakcije sa replikacionim proteinom A1,^[3] ORC3L,^[3] retinoblastoma protein,^[4] MCM5,^[3][5][6] MCM6,^[3][5][7][8] ORC1L,^[3] ORC2L,^[3] ORC5L,^[3] MCM4,^[5][7][8][9] MCM3,^{[3][5][10][11]} CDC6,^[3][10] MNAT1,^[12] DBF4,^[3] MCM2,^{[3][5][7][8][13]} UBE3A,^[14] CDC45-srodni protein^[3][15] i CDC7.^[3]

Reference

1. Nakatsuru S, Sudo K, Nakamura Y (March 1995). „Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication”. Cytogenet Cell Genet 68 (3-4): 226–30. DOI:10.1159/000133918. PMID 7842741.
2. „Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)”.
3. Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (March 2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. (England) 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.
4. Sterner, J M; Dew-Knight S; Musahl C; Kornbluth S; Horowitz J M (May 1998). „Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7”. Mol. Cell. Biol. (UNITED STATES) 18 (5): 2748–57. ISSN 0270-7306. PMC 110654. PMID 9566894.
5. Fujita, M; Kiyono T; Hayashi Y; Ishibashi M (April 1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. DOI:10.1074/jbc.272.16.10928. ISSN 0021-9258. PMID 9099751.
6. DaFonseca, C J; Shu F; Zhang J J (March 2001). „Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma”. Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. DOI:10.1073/pnas.061487598. ISSN 0027-8424. PMC 30602. PMID 11248027.
7. Yabuta, Norikazu; Kajimura Naoko; Mayanagi Kouta; Sato Michio; Gotow Takahito; Uchiyama Yasuo; Ishimi Yukio; Nojima Hiroshi (May 2003). „Mammalian Mcm2/4/6/7 complex forms a toroidal structure”. Genes Cells (England) 8 (5): 413–21. DOI:10.1046/j.1365-2443.2003.00645.x. ISSN 1356-9597. PMID 12694531.
8. You, Zhiying; Ishimi Yukio; Masai Hisao; Hanaoka Fumio (November 2002). „Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex”. J. Biol. Chem. (United States) 277 (45): 42471–9. DOI:10.1074/jbc.M205769200. ISSN 0021-9258. PMID 12207017.
9. Ishimi, Y; Ichinose S; Omori A; Sato K; Kimura H (September 1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. (UNITED STATES) 271 (39): 24115–22. DOI:10.1074/jbc.271.39.24115. ISSN 0021-9258. PMID 8798650.
10. Fujita, M; Yamada C; Goto H; Yokoyama N; Kuzushima K; Inagaki M; Tsurumi T (September 1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation”. J. Biol. Chem. (UNITED STATES) 274 (36): 25927–32. DOI:10.1074/jbc.274.36.25927. ISSN 0021-9258. PMID 10464337.
11. Fujita, Masatoshi; Ishimi Yukio; Nakamura Hiromu; Kiyono Tohru; Tsurumi Tatsuya (March 2002). „Nuclear organization of DNA replication initiation proteins in mammalian cells”. J. Biol. Chem. (United States) 277 (12): 10354–61. DOI:10.1074/jbc.M111398200. ISSN 0021-9258. PMID 11779870.
12. Wang, Y; Xu F; Hall F L (October 2000). „The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor”. FEBS Lett. (NETHERLANDS) 484 (1): 17–21. DOI:10.1016/S0014-5793(00)02117-7. ISSN 0014-5793. PMID 11056214.
13. You, Z; Komamura Y; Ishimi Y (December 1999). „Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity”. Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003–15. ISSN 0270-7306. PMC 84885. PMID 10567526.
14. Kühne, C; Banks L (December 1998). „E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box”. J. Biol. Chem. (UNITED STATES) 273 (51): 34302–9. DOI:10.1074/jbc.273.51.34302. ISSN 0021-9258. PMID 9852095.
15. Kukimoto, I; Igaki H; Kanda T (November 1999). „Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha”. Eur. J. Biochem. (GERMANY) 265 (3): 936–43. DOI:10.1046/j.1432-1327.1999.00791.x. ISSN 0014-2956. PMID 10518787.

Literatura

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• Sterner JM, Dew-Knight S, Musahl C, et al. (1998). „Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.”. Mol. Cell. Biol. 18 (5): 2748–57. PMC 110654. PMID 9566894.
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• Kühne C, Banks L (1999). „E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box.”. J. Biol. Chem. 273 (51): 34302–9. DOI:10.1074/jbc.273.51.34302. PMID 9852095.
• Fujita M, Yamada C, Goto H, et al. (1999). „Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.”. J. Biol. Chem. 274 (36): 25927–32. DOI:10.1074/jbc.274.36.25927. PMID 10464337.
• Freeman A, Morris LS, Mills AD, et al. (1999). „Minichromosome maintenance proteins as biological markers of dysplasia and malignancy.”. Clin. Cancer Res. 5 (8): 2121–32. PMID 10473096.
• Kukimoto I, Igaki H, Kanda T (1999). „Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha.”. Eur. J. Biochem. 265 (3): 936–43. DOI:10.1046/j.1432-1327.1999.00791.x. PMID 10518787.