LPAR4

LPAR4, receptor lizofosfatidne kiseline 4 ili LPA₄, je protein koji je kod čoveka kodiran LPAR4 genom.^[1][2][3] LPA₄ je G protein-spregnuti receptor koji vezuje lipidni signalni molekul lizofosfatidnu kiselinu (LPA).^[4]

edit

Receptor lizofosfatidne kiseline 4
Identifikatori
Simboli	LPAR4; GPR23; LPA4; P2RY9; P2Y5-LIKE; P2Y9
Vanjski ID	OMIM: 300086 MGI: 1925384 HomoloGene: 3871 IUPHAR: GeneCards: LPAR4 Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • vezivanje lipida • aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog Celularna komponenta • integralno sa ćelijskom membranom • membrana Biološki proces • prenos signala • signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2846	78134
Ensembl	ENSG00000147145	ENSMUSG00000049929
UniProt	Q99677	Q80UD5
RefSeq (mRNA)	NM_005296	NM_175271
RefSeq (protein)	NP_005287	NP_780480
Lokacija (UCSC)	Chr X: 77.9 - 77.9 Mb	Chr X: 103.12 - 103.14 Mb
PubMed pretraga

Povezano

• Lizofosfolipidni receptor
• P2Y receptor

Reference

1. „Entrez Gene: GPR23 G protein-coupled receptor 23”.
2. Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). „Cloning of a human heptahelical receptor closely related to the P2Y5 receptor”. Biochem. Biophys. Res. Commun. 236 (1): 106–12. DOI:10.1006/bbrc.1997.6895. PMID 9223435.
3. O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). „Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes”. Gene 187 (1): 75–81. DOI:10.1016/S0378-1119(96)00722-6. PMID 9073069.
4. Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). „LPA Receptors: Subtypes and Biological Actions”. Annual Review of Pharmacology and Toxicology 50 (1): 157–186. DOI:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.^{[mrtav link]}

Literatura

• Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). „Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.”. Biochim. Biophys. Acta 1492 (1): 127–38. PMID 11004484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Noguchi K, Ishii S, Shimizu T (2003). „Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.”. J. Biol. Chem. 278 (28): 25600–6. DOI:10.1074/jbc.M302648200. PMID 12724320.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). „The DNA sequence of the human X chromosome.”. Nature 434 (7031): 325–37. DOI:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). „Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.”. J. Proteome Res. 4 (6): 2070–80. DOI:10.1021/pr0502065. PMC 1850943. PMID 16335952.