Folitropinska podjedinica beta

Folitropinska podjedinica beta (beta podjedica folikostimulišućeg hormona, FSH-B) je protein koji je kod ljudi kodiran FSHB genom.^[1][2][3] Alternativno splajsovanje proizvodi dve transkriptne varijante koji kodiraju isti protein.

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Folikostimulišući hormon, beta polipeptid
PDB prikaz baziran na 1fl7.
Dostupne strukture
1FL7, 1XWD, 4AY9
Identifikatori
Simbol	FSHB
Vanjski ID	OMIM: 136530 MGI: 95582 HomoloGene: 430 GeneCards: FSHB Gene
Ontologija gena Molekularna funkcija • hormonska aktivnost • proteinsko vezivanje • aktivnost folikostimulišućeg hormona • aktivnost proteinske heterodimerizacije Celularna komponenta • ekstracelularni region • citoplazma Biološki proces • razvoj folikula jajnika • proces biosinteze progesterona • prenos signala
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2488	14308
Ensembl	ENSG00000131808	ENSMUSG00000027120
UniProt	P01225	Q60687
RefSeq (mRNA)	NM_000510.2	NM_008045.2
RefSeq (protein)	NP_000501.1	NP_032071.1
Lokacija (UCSC)	Chr 11: 30.25 - 30.26 Mb	Chr 2: 107.06 - 107.06 Mb
PubMed pretraga

Funkcija

Hipofizna glikoproteinska hormonska familija obuhvata folikulostimulišući hormon, luteinizirajući hormon, humani horionski gonadotropin, i tireostimulišući hormon. Svi ti glikoproteini sadrže identičnu alfa podjedinicu i hormon specifičnu beta podjedinicu. Ovaj gen kodira beta podjedinicu folikul-stimulišućeg hormona. Zajedno sa luteinizirajućim hormonom, folikulostimulišuć hormon indukuje produkciju jaja i sperme.^[3]

Reference

1. Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB (Aug 1987). „DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11”. DNA 6 (3): 205–12. DOI:10.1089/dna.1987.6.205. PMID 2885163.
2. Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). „A reevaluation of the amino acid sequence of human follitropin beta-subunit”. J Protein Chem 7 (4): 325–39. DOI:10.1007/BF01024882. PMID 3151250.
3. „Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide”.

Literatura

• Barrios-De-Tomasi J, Timossi C, Merchant H i dr.. (2002). „Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones”. Mol. Cell. Endocrinol. 186 (2): 189–98. DOI:10.1016/S0303-7207(01)00657-8. PMID 11900895.
• Saxena BB, Rathnam P (1976). „Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands”. J. Biol. Chem. 251 (4): 993–1005. PMID 1249074.
• Keene JL, Matzuk MM, Otani T i dr.. (1989). „Expression of biologically active human follitropin in Chinese hamster ovary cells”. J. Biol. Chem. 264 (9): 4769–75. PMID 2494176.
• Jameson JL, Becker CB, Lindell CM, Habener JF (1988). „Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids”. Mol. Endocrinol. 2 (9): 806–15. DOI:10.1210/mend-2-9-806. PMID 3139991.
• Shome B, Parlow AF (1974). „Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb)”. J. Clin. Endocrinol. Metab. 39 (1): 203–5. DOI:10.1210/jcem-39-1-203. PMID 4835136.
• Fujiki Y, Rathnam P, Saxena BB (1980). „Studies on the disulfide bonds in human pituitary follicle-stimulating hormone”. Biochim. Biophys. Acta 624 (2): 428–35. PMID 6774759.
• Böckers TM, Nieschlag E, Kreutz MR, Bergmann M (1995). „Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men”. Cell Tissue Res. 278 (3): 595–600. DOI:10.1007/BF00331379. PMID 7850869.
• Matthews CH, Borgato S, Beck-Peccoz P i dr.. (1993). „Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone”. Nat. Genet. 5 (1): 83–6. DOI:10.1038/ng0993-83. PMID 8220432.
• Layman LC, Lee EJ, Peak DB i dr.. (1997). „Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene”. N. Engl. J. Med. 337 (9): 607–11. DOI:10.1056/NEJM199708283370905. PMID 9271483.
• Cargill M, Altshuler D, Ireland J i dr.. (1999). „Characterization of single-nucleotide polymorphisms in coding regions of human genes”. Nat. Genet. 22 (3): 231–8. DOI:10.1038/10290. PMID 10391209.
• Grasso P, Rozhavskaya-Arena M, Reichert LE (1999). „Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle”. Regul. Pept. 81 (1–3): 67–71. DOI:10.1016/S0167-0115(99)00022-1. PMID 10395410.
• Ben-Menahem D, Hyde R, Pixley M i dr.. (1999). „Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation”. Biochemistry 38 (46): 15070–7. DOI:10.1021/bi991510c. PMID 10563789.
• Dias Neto E, Correa RG, Verjovski-Almeida S i dr.. (2000). „Shotgun sequencing of the human transcriptome with ORF expressed sequence tags”. Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. DOI:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Hartley JL, Temple GF, Brasch MA (2001). „DNA Cloning Using In Vitro Site-Specific Recombination”. Genome Res. 10 (11): 1788–95. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Fox KM, Dias JA, Van Roey P (2001). „Three-dimensional structure of human follicle-stimulating hormone”. Mol. Endocrinol. 15 (3): 378–89. DOI:10.1210/me.15.3.378. PMID 11222739.
• Amoresano A, Orrù S, Siciliano RA i dr.. (2002). „Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain”. Biol. Chem. 382 (6): 961–8. DOI:10.1515/BC.2001.120. PMID 11501762.
• Walton WJ, Nguyen VT, Butnev VY i dr.. (2001). „Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit”. J. Clin. Endocrinol. Metab. 86 (8): 3675–85. DOI:10.1210/jc.86.8.3675. PMID 11502795.