Kompleks prepoznavanja mesta početka 4

Kompleks prepoznavanja mesta početka 4 je protein koji je kod ljudi kodiran ORC4 (ORC4L) genom.^[1][2][3]

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Kompleks prepoznavanja mesta početka, podjedinica 4
Identifikatori
Simboli	ORC4; ORC4L; ORC4P
Vanjski ID	OMIM: 603056 MGI: 1347043 HomoloGene: 8059 GeneCards: ORC4 Gene
Ontologija gena Molekulska funkcija • nucleotidno vezivanje • vezivanje za meto početka DNK replikacije • proteinsko vezivanje Ćelijska komponenta • Kompleks prepoznavanja mesta početka • nukleus • nukleoplazma Biološki proces • kontrolna tačka ćelijskog ciklusa • G1/S tranzicija mitotičkog ćelijskog ciklusa • S faza mitotičkog ćelijskog ciklusa
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	5000	26428
Ensembl	ENSG00000115947	ENSMUSG00000026761
UniProt	O43929	O88708
Ref. Sekv. (iRNK)	NM_001190879	NM_001177313
Ref. Sekv. (protein)	NP_001177808	NP_001170784
Lokacija (UCSC)	Chr 2: 148.69 - 148.78 Mb	Chr 2: 48.9 - 48.95 Mb
PubMed pretraga

Kompleks prepoznavanja mesta početka (ORC) je visoko konzervirani proteinski kompleks sa šest podjedinica koji je esencijalan za inicijaciju replikacije DNK kod eukariotskih ćelija. Istraživanja na kvascu su pokazala da se ORC specifično vezuje za mesto početka replikacije i da služi kao platforma za konstrukciju prereplikacionog kompleksa, koji sadrži dodatne inicijacione faktore kao što su Cdc6 i Mcm proteini. Protein kodiran ovim genom je podjedinica kompleksa prepoznavanja mesta početka. Pokazano je da formira sržni kompleks sa ORC2L, -3L, i -5L. Tri alternativno splajsovane transkriptne varijante kodiraju isti protein.^[3]

Interakcije

ORC4 mođe da formira interakcije sa ORC1,^[4] MCM6,^[4] ORC2,^[1][4][5][6] ORC5,^[4][5][7] ORC3,^[5][6][8] MCM2,^[4] MCM4,^[4] MCM3^[4] i ORC6.^[4]

Reference

1. Quintana DG, Hou Zh, Thome KC, Hendricks M, Saha P, Dutta A (December 1997). „Identification of HsORC4, a member of the human origin of replication recognition complex”. J Biol Chem 272 (45): 28247–51. DOI:10.1074/jbc.272.45.28247. PMID 9353276.
2. Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). „Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis”. Cytogenet Cell Genet 81 (1): 89–90. DOI:10.1159/000014997. PMID 9691185.
3. „Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)”.
4. Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (March 2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. (England) 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.
5. Dhar, S K; Delmolino L, Dutta A (August 2001). „Architecture of the human origin recognition complex”. J. Biol. Chem. (United States) 276 (31): 29067–71. DOI:10.1074/jbc.M103078200. ISSN 0021-9258. PMID 11395502.
6. Vashee, S; Simancek P, Challberg M D, Kelly T J (July 2001). „Assembly of the human origin recognition complex”. J. Biol. Chem. (United States) 276 (28): 26666–73. DOI:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433.
7. Quintana, D G; Thome K C, Hou Z H, Ligon A H, Morton C C, Dutta A (October 1998). „ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases”. J. Biol. Chem. (UNITED STATES) 273 (42): 27137–45. DOI:10.1074/jbc.273.42.27137. ISSN 0021-9258. PMID 9765232.
8. Pinto, S; Quintana D G, Smith P, Mihalek R M, Hou Z H, Boynton S, Jones C J, Hendricks M, Velinzon K, Wohlschlegel J A, Austin R J, Lane W S, Tully T, Dutta A (May 1999). „latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant”. Neuron (UNITED STATES) 23 (1): 45–54. DOI:10.1016/S0896-6273(00)80752-7. ISSN 0896-6273. PMID 10402192.

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