Glukagonski receptor je 62 kDa težak protein koji se aktivira glukagonom. On je član klase B G protein spregnutih receptora. On formira spregu sa G alfa i, Gs i u manjoj meri G alfa q.[1] Stimulacija receptora dovodi do aktivacije adenilat ciklaze i povišenja nivoa intracelularnog cAMP. Kod ljudi, glukagonski receptor je kodiran GCGR genom.[2][3]
Kratke činjenice Dostupne strukture, Identifikatori ...
Zatvori
Glukagonski receptori su uglavnom izraženi u jetri i bugrezima, i u manjim razmeri u srcu, adipoznom tkivu, slezini, grudnoj žledi, nadbubrežnim žlezdama, pankreasu, cerebralnom korteksu, i gastrointestinalnom traktu.
Jedna od mutacija GCGR gena je vezana za dijabetes melitus tip 2.[4]
Inaktivirajuća mutacija glukagonskog receptora kod ljudi uzrokuje otpornost na glukagon, te je povezana sa hiperplazijom pankreasnih alfa ćelija, nezidioblastozom, hiperglukagonemijom, i pankreasnim neuroendokrinim tumorima.[5]
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