Angiotensin-konvertujući enzim 2

Angiotensin-konvertujući enzim 2 (EC 3.4.17.23, ACE-2, ACE2, hACE2, angiotenzin konvertujući enzim 2, angiotenzin konvertujući enzim-2, Tmem27) je enzim.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

angiotenzin II + H₂O ${\displaystyle \rightleftharpoons }$ angiotenzin-(1--7) + L-fenilalanin

Angiotensin-konvertujući enzim 2
Identifikatori
EC broj	3.4.17.23
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Ovaj transmembranski glikoprotein sadrži ektracelularni katalitički domen.

Reference

1. Vickers, C., Hales, P., Kaushik, V., Dick, L., Gavin, J., Tang, J., Godbout, K., Parsons, T., Baronas, E., Hsieh, F., Acton, S., Patane, M., Nichols, A. and Tummino, P. (2002). „Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase”. J. Biol. Chem. 277: 14838-14843. PMID 11815627.
2. Lambert, D.W., Hooper, N.M. and Turner, A.J. (2008). „Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system”. Biochem. Pharmacol. 75: 781-786. PMID 17897633.
3. Towler, P., Staker, B., Prasad, S.G., Menon, S., Tang, J., Parsons, T., Ryan, D., Fisher, M., Williams, D., Dales, N.A., Patane, M.A. and Pantoliano, M.W. (2004). „ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis”. J. Biol. Chem. 279: 17996-18007. PMID 14754895.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

• MeSH Angiotensin-converting+enzyme+2