Lo Coenzim A (CoA) es un coenzim de transferiment de grops acil intervenant dins un fum de vias del metabolisme (cicle de Krebs, beta-oxidacion).
1: Adenosina 3'Fòsfat 2: DiFòsfat 3: Acide Pantoïca 4: Beta-Alanina 5: Tioetanolamina ( 3 + 4 = Acid Pantotenic )
Deriva de la vitamina B5. Es un coenzim liure.
Sa part reactiva es la foncion tiòl (-SH) de la tioetanolamine e es fòrça sovent simbolizat per HS-CoA (o CoA-SH). Ansin, la reaccion amb un acid carboxilic forma un ligam ric en energia aciltioester.
Reaccion : CoA-SH + R-COOH => CoA-S-CO-R ( + H2O )
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