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Receptorium dopaminae D2 cum scientiae abbreviatura DR2 est proteinum et in cerebro receptorium principale industriarum substantiarum antipsychoticarum. In hominibus in chromosomate 11 (11q23.2) locati geni nomen est DRD2[1]. Nonnullae mutationes adhuc notae sunt.
Post receptorii dopaminae D2 stimulationem intra cellulam synthesis cAMP inhibitur. Receptorium dopaminae D2 duae formae exstat, altera enim longa, D2L, altera stricta, D2S. Ambae formae geno D2D legunter, sed forma D2L breviori undetriginta acidis aminicis ligamentuculum intracellulare tertium longiore est[2]. Adhuc ligandi utraeque formae non sunt.
Exempli sunt:
| Substantia ligandus | Codex ATC | D2 Ki (nM)[3] | D2L Ki (nM) | D2S Ki (nM) | Annotatio |
|---|---|---|---|---|---|
| Haloperidolum | N05AD01 | 1.55 | |||
| Melperonum | N05AD03 | 194 | |||
| Norquetiapinum | N05AH04 | 196 | Norquetiapinum est metabolitus Quetiapini | ||
| Risperidonum | N05AX08 | 3.57 | 4.16 | 4.73 | |
| Amitriptylinum | N06AA09 | 196–1,460 | |||
| Nortriptylinum | N06AA10 | 2,570 | Nortriptylinum est metabolitus Amitriptylini |
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